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Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia

By Deborah Bongiovanni, Valentina Saccomani and Erich Piovan

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomic landscape of T-ALL has been the target of intense research. The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth. Notwithstanding, T-ALL patients are still treated with high-dose multiagent chemotherapy, potentially exposing these patients to considerable acute and long-term side effects. This review summarizes recent advances in our understanding of the signaling pathways relevant for the pathogenesis of T-ALL and the opportunities offered for targeted therapy

Topics: acute lymphoblastic leukemia, oncogenes, PI3K/AKT, targeted therapy, Biology (General), QH301-705.5, Chemistry, QD1-999
Publisher: MDPI AG
Year: 2017
DOI identifier: 10.3390/ijms18091904
OAI identifier: oai:doaj.org/article:3c5ea7823b34437093653b337164c2fd
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