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New flavone and other compounds from Tephrosia egregia: assessing the cytotoxic effect on human tumor cell lines

By Maria V.S. Teixeira, Jefferson Q. Lima, Antônia T.A. Pimenta, Francisca R.L. da Silva, Maria da Conceição F. de Oliveira, Italo G. Pereira, Dilailson C. Costa-Junior, Paulo R.V. Ribeiro, Gilvandete M.P. Santiago, Mary Anne S. Lima, Raimundo Braz-Filho, Mirna M. Bezerra, Raquel C. Montenegro, Danilo D. Rocha, Maria Elisabete A. de Moraes, Aline C. de Medeiros and Angela M.C. Arriaga


ABSTRACT The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided a new flavone, 5-hydroxy-8-(1",2"-epoxy-3"-hydroxy-3"-methylbutyl)-7-methoxyflavone (1), in addition to eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecansone A, 2',6'-dimethoxy-4',5'-(2",2"-dimethyl)-pyranochalcone, pongachalcone, maackiain, β-sistosterol and its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were established on the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison with literature data. Cytotoxicity of compounds 1–4 was evaluated against AGP-01 (cancerous ascitic fluid), HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma) and SKMEL 28 (melanoma) cell lines

Topics: Tephrosia, Flavone, Flavonoids, Cytotoxicity activity, Pharmacy and materia medica, RS1-441
Publisher: Elsevier
DOI identifier: 10.1016/j.bjp.2018.03.008
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