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Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

By Carl A. Nist-Lund, Bifeng Pan, Amy Patterson, Yukako Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, Daniel B. Polley, Gwenaelle S. Géléoc and Jeffrey R. Holt


Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice

Topics: Science, Q
Publisher: Nature Publishing Group
Year: 2019
DOI identifier: 10.1038/s41467-018-08264-w
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