Article thumbnail

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

By Carl A. Nist-Lund, Bifeng Pan, Amy Patterson, Yukako Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, Daniel B. Polley, Gwenaelle S. Géléoc and Jeffrey R. Holt

Abstract

Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice

Topics: Science, Q
Publisher: Nature Publishing Group
Year: 2019
DOI identifier: 10.1038/s41467-018-08264-w
OAI identifier: oai:doaj.org/article:50b8bfda3b5c44479a3106fe7491cf81
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2041-1723 (external link)
  • http://link.springer.com/artic... (external link)
  • https://doaj.org/article/50b8b... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.