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Regio- and stereochemical aspects of the asymmetric Michael addition using chiral imines bearing a resident stereogenic center

By Rossana A. Schenato, Éverton M. dos Santos, Beatriz S. M. Tenius and Eduardo R. de Oliveira


The asymmetric Michael addition reactions using chiral imines, under neutral conditions (deracemizing alkylation process), constitute one of the main methods for the stereocontrolled elaboration of quaternary carbon centers. This protocol is based on the conjugate addition of secondary chiral enamines to electron-deficient alkenes. The focus of this report deals with the discussion of regio- and stereochemical aspects of the deracemizing alkylation process concerning enamines bearing a resident chiral center

Topics: deracemizing alkylation process, chiral imines, transmission of chirality
Publisher: Sociedade Brasileira de Química
Year: 2003
OAI identifier: oai:scielo:S0100-40422003000500016
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