Skip to main content
Article thumbnail
Location of Repository

Characterization and solubility study of binary mixtures of flunarizine/ polyethylene glycol 4000

By María Teresa Marín Boscá, María Victoria Margarit Bellver and Daniel Martín-Ramos

Abstract

En este trabajo estudiamos las interacciones de la flunarizina con polietilenglicol 4000 en dispersiones sólidas preparadas siguiendo el método de disolución propuesto por Sekiguchi y Obi. Como elementos de comparación se han utilizado mezclas físicas de ambos componentes, preparados en las mismas proporciones de fármaco/polímero: 10/ 90, 20/80, 30/70, 40/60, 50/50,60/40 y 80/20. Las propiedades fisicoquímicas de las dispersiones sólidas y mezclas físicas se investigan mediante espectroscopía infrarroja,difracción de rayos X, calorimetría diferencial de barrido y solubilidad en equilibrio. Los espectros de infrarrojo indican que no ha habido interacción química entre la flunarizina y el PEG. Los difractogramas muestran que a determinadas proporciones, el PEG se introduce en la estructura de la flunarizina y los estudios térmicos parecen indicar la formación de una mezcla eutéctica a la proporción 28,96% de flunarizina y 71,04% de PEG 4000. Todas las muestras presentan una solubilidad superior a la del fármaco puro y en ambos tipos de muestras el incremento es mayor al aumentar la proporción de polímero. El análisis de comparación múltiple aplicado independientemente a las dispersiones sólidas y mezclas físicas, indica que no existe diferencia estadísticamente significativa (p<0,05) entre las muestras de proporciones 30/70, 40/60, 50/50 y 60/40, pero sí hay diferencias entre éstas y las de proporciones 10/90, 20/80 y 80/20.In this report interactions of flunarizine and polyethylene glycol 4000 in solid dispersions prepared according to the dissolution method proposed by Sekiguchi and Obi, have been investigated. For purposes of comparison, physical mixtures were prepared at the same drug/polymer percentage proportions: 10/90, 20/80, 30/70, 40/60, 50/50, 60/40 and 80/20. The physicochemical properties of both kinds of sample were investigated with infrared spectroscopy, X-Ray diffraction, differential scanning calorimetry and solubility in equilibrium. Infrared spectra suggested that no chemical interaction between flunarizine and polyethylene glycol 4000 had taken place. X-Ray patterns have shown that at certain proportions, polyethylene glycol is bonded within the flunarizine structure. Differential scanning calorimetry indicated that the formation of an eutectic mixture becomes apparent at a drug/polymer ratio of 28.96/71.04. Equilibrium solubility studies showed that drug solubility was enhanced as the polymer content in the samples increased. The Multiple range test (LSD) applied independently to solid dispersions, and to physical mixtures, revealed that the samples of drug/polymer proportions of 30/70, 40/60, 50/50 and 60/40 did not produce statistically significant differences (p<0.05). However, differences were detected between these proportions and samples with a drug/polymer ratio of 10/ 90, 20/80 and 80/20

Topics: Flunarizina, Flunarizine, Polietilenglicol 4000, Polyethylene glycol 4000, Dispersiones sólidas, Solid dispersions, Solubilidad, Solubility
Publisher: Universidad de Granada, Facultad de Farmacia
Year: 2002
OAI identifier: oai:digibug.ugr.es:10481/28243
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://hdl.handle.net/10481/28... (external link)
  • http://hdl.handle.net/10481/28... (external link)
  • http://creativecommons.org/lic... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.