Skip to main content
Article thumbnail
Location of Repository

Functional roles of nitric oxide signalling during zebrafish nervous system development

By Sophie Bradley


Nitric oxide (NO) is a highly diffusible signalling molecule that serves a wide range of physiological functions. During development, biosynthetic enzymes for NO are often expressed in nascent neurons, although little is known of how this molecule regulates in vivo nervous system development. This thesis aims to address this problem by examining the functional roles of NO signalling in the zebrafish embryo, focusing specifically on nitrergic regulation of spinal locomotor network assembly.\ud The first aim of this study is to characterise the spatiotemporal distribution of NO synthase 1 (NOS1), the enzyme responsible for NO biosynthesis in the zebrafish nervous system. NOS1 transcript and protein was observed in discrete regions of the brain as well as a distinct class of spinal interneuron from early stages of embryonic development.\ud The second aim was to examine functional roles of NO signalling during in vivo spinal cord development. Using molecular antisense and pharmacological approaches, NO levels were disrupted during early life and the consequences to spinal circuit maturation assessed. NO was found to specifically regulate the growth of spinal motoneurons that innervate axial trunk muscles. Abrogation of NO signalling dramatically increased the number of motor axon branches formed within the muscle across the first three days of life whilst exogenous elevation of NO levels had the opposite effect.\ud The third aim was to determine downstream signalling pathways underpinning NOs effects. Pharmacological studies revealed that NO regulates motoneuron branching through the cyclic guanosine monophosphate pathway and subsequent analysis revealed that this pathway can modify neuromuscular synapse density, with high NO levels suppressing synaptogenesis and retarding locomotor maturation and low NO levels having the converse effect.\ud In summary, the work presented in this thesis identifies a novel and important role for NO signalling, demonstrating that it functions to sculpt neuromuscular synapse assembly and modify locomotor maturation

Publisher: University of Leicester
Year: 2011
OAI identifier:

Suggested articles


  1. (2007). Pharmacological approaches to nitric oxide signalling during neural development of locusts and other model insects.
  2. (2009). Cyclic nucleotide-regulated cation channels.
  3. (2005). Genetic screens for genes controlling motor nerve-muscle development and interactions.
  4. (2005). Nitric oxide, cell signaling and cell death.
  5. (2001). Just in time and place: NOS/NO system assembly in neuromuscular junction formation.
  6. (1994). Nitric oxide synthase inhibition and platelet function.
  7. (2001). Nitric oxide and the immune response.
  8. (2004). Nitric oxide neurotoxicity in neurodegenerative diseases.
  9. (2001). Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway.
  10. (2003). On the role of nitric oxide in hippocampal long-term potentiation.
  11. (2005). Regulation of cyclic nucleotide-gated channels.
  12. (2010). Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons.
  13. (1998). A good antisense molecule is hard to find.
  14. (1991). Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase.
  15. (1991). Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
  16. (1990). Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
  17. (1992). Nitric oxide, a novel neuronal messenger.
  18. (1996). Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.
  19. (1996). Cloning and characterization of postsynaptic density 93, a nitric oxide synthase interacting protein.
  20. (1997). Regulation of neuronal nitric oxide synthase through alternative transcripts.
  21. (1996). Direct activation of the olfactory cyclic nucleotide-gated channel through modification of sulfhydryl groups by NO compounds.
  22. (2010). Nitric oxide and neuronal death.
  23. (2005). The basics about nitric oxide.
  24. (1996). Localization of nitric oxide synthase in the brain of the frog, Xenopus laevis.
  25. (1996). Prenatal development of nitric oxide synthase in the mouse spinal cord.
  26. (2001). Nitric oxide synthase in the spinal cord of the frog, Xenopus laevis.
  27. (2003). Steps during the development of the zebrafish locomotor network.
  28. (2009). Discovery of the nitric oxide signaling pathway and targets for drug development.
  29. (2000). Locomotor repertoire of the larval zebrafish: swimming, turning and prey capture.
  30. (1991). Expression of soluble guanylate cyclase activity requires both enzyme subunits.
  31. (2000). Physiological properties of zebrafish embryonic red and white muscle fibers during early development.
  32. (2002). Activation of embryonic red and white muscle fibers during fictive swimming in the developing zebrafish.
  33. (2007). Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity.
  34. (2000). Acute blockade of nitric oxide synthesis induces disorganization and amplifies lesion-induced plasticity in the rat retinotectal projection.
  35. (2007). Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain.
  36. (2007). alpha2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents.
  37. (2005). Protein nitration in a mouse model of familial amyotrophic lateral sclerosis: possible multifunctional role in the pathogenesis.
  38. (1994). Immunohistochemical demonstration of nitric oxide synthase in the peripheral autonomic nervous system.
  39. (1997). Nitric oxide synthase and cyclic GMP-dependent protein kinase concentrated at the neuromuscular endplate.
  40. (2006). NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1.
  41. (2004). Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.
  42. (2008). Protein tyrosine nitration of the flavin subunit is associated with oxidative modification of mitochondrial complex II in the post-ischemic myocardium.
  43. (2004). The localization of neuronal nitric oxide synthase may influence its role in neuronal precursor proliferation and synaptic maintenance.
  44. (2008). Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective.
  45. (2008). Involvement of CAPON and nitric oxide synthases in rat muscle regeneration after peripheral nerve injury.
  46. (2001). Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity.
  47. (2008). Expression of CAPON after spinal cord injury in rats.
  48. (2006). The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.
  49. (1982). Role of endothelial cells in relaxation of isolated arteries by bradykinin.
  50. (2010). Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease.
  51. (2000). Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation.
  52. (1999). PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
  53. (2005). Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain.
  54. (2006). Say NO to neurodegeneration: role of S-nitrosylation in neurodegenerative disorders.
  55. (2004). Distribution of neuronal nitric oxide synthaseimmunoreactive neurons in the cerebral cortex and hippocampus during postnatal development.
  56. (2006). Proliferation of cerebellar precursor cells is negatively regulated by nitric oxide in newborn rat.
  57. (1987). N-methyl-D-aspartate receptor antagonist desegregates eye-specific stripes.
  58. (2000). Nitric oxide modulates retinal ganglion cell axon arbor remodeling in vivo.
  59. (2001). Nitric oxide in immunity and inflammation.
  60. (1993). Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction.
  61. (2000). Roles of NMDA receptor activity and nitric oxide production in brain development.
  62. (2004). Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation.
  63. (2003). Brain nitric oxide and its dual role in neurodegeneration/neuroprotection: understanding molecular mechanisms to devise drug approaches.
  64. (2006). Plasticity in the human central nervous system.
  65. (2000). Phosphorylation of
  66. (1999). The neuronal form of nitric oxide synthase is required for pattern formation by retinal afferents in the ferret lateral geniculate nucleus.
  67. (1999). N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
  68. (2004). Nitric oxide synthase expression and cell changes in dorsal root ganglia and spinal dorsal horn of developing and adult Rana esculenta indicate a role of nitric oxide in limb metamorphosis.
  69. (1995). Distribution of NADPHdiaphorase reactivity in the spinal cord of metamorphosing and adult Xenopus laevis.
  70. (2011). Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury.
  71. (2010). NO synthase: structures and mechanisms.
  72. (2006). Learning from small fry: the zebrafish as a genetic model organism for aquaculture fish species.
  73. (1987). The morphology and distribution of 'Kolmer-Agduhr cells', a class of derebrospinal-fluid-contacting neurons revealed in the frog embryo spinal cord by GABA immunocytochemistry.
  74. (2009). Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.
  75. (1991). Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
  76. (1992). A novel neuronal messenger molecule
  77. (2000). NO-mediated cGMP synthesis in cholinergic neurons in the rat forebrain: effects of lesioning dopaminergic or serotonergic pathways on nNOS and cGMP synthesis.
  78. (2002). Motor effects of acute and chronic inhibition of nitric oxide synthesis in mice.
  79. (2009). Biochemistry of soluble guanylate cyclase. Handb Exp Pharmacol,
  80. (1993). Ontogenesis of NADPH-diaphorase neurons in the mouse forebrain.
  81. (1994). Laminar pattern of NADPH-diaphorase activity in the developing avian cerebellum.
  82. (2001). Changes in NADPH diaphorase expression in the fish visual system during optic nerve regeneration and retinal development.
  83. (1996). Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation.
  84. (2006). 7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study.
  85. (2002). Molecular mechanisms of axon guidance.
  86. (1998). The deactivation of soluble guanylyl cyclase by redoxactive agents.
  87. (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.
  88. (2007). Cyclic guanosine monophosphate signalling pathway plays a role in neural cell adhesion moleculemediated neurite outgrowth and survival.
  89. (2011). A parsimonious model for gene regulation by miRNAs.
  90. (2002). Development of the locomotor network in zebrafish.
  91. (1994). Zebrafish: genetic tools for studying vertebrate development.
  92. (2007). S-nitrosylation/denitrosylation and apoptosis of immune cells.
  93. (2006). The regulation and pharmacology of endothelial nitric oxide synthase.
  94. (2007). Life history of eNOS: partners and pathways.
  95. (1993). Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord.
  96. (1997). New and potent inhibitors of nitric oxide synthase reduce motor activity in mice.
  97. (1991). NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway.
  98. (1991). Determination of primary motoneuron identity in developing zebrafish embryos.
  99. (1991). The spt-1 mutation alters segmental arrangement and axonal development of identified neurons in the spinal cord of the embryonic zebrafish.
  100. (1989). The growth cones of identified motoneurons
  101. (2000). Morphants: a new systematic vertebrate functional genomics approach.
  102. (2003). Thr123 of rat G-substrate contributes to its action as a protein phosphatase inhibitor.
  103. (1999). Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells.
  104. (2007). Zebrafish in the wild: a review of natural history and new notes from the field.
  105. (2000). Stabilization of growing retinal axons by the combined signaling of nitric oxide and brain-derived neurotrophic factor.
  106. (1999). NMDA receptor-mediated refinement of a transient retinotectal projection during development requires nitric oxide.
  107. (1998). Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson's disease.
  108. (2010). Regulation of mRNA translation and stability by microRNAs.
  109. (2000). Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON.
  110. (1999). Secondary motoneuron axons localize DM-GRASP on their fasciculated segments.
  111. (2008). NO/cGMP-dependent modulation of synaptic transmission. Handb Exp Pharmacol,
  112. (2005). Neuropilin-1a is involved in trunk motor axon outgrowth in embryonic zebrafish.
  113. (2007). PlexinA3 restricts spinal exit points and branching of trunk motor nerves in embryonic zebrafish.
  114. (2000). Nitric oxide-sensitive guanylyl cyclase activity inhibition through cyclic GMP-dependent dephosphorylation.
  115. (2008). Zebrafish and motor control over the last decade.
  116. (1991). Single odor-sensitive channels in olfactory receptor neurons are also gated by cyclic nucleotides.
  117. (1992). Structure and early embryonic expression of the zebrafish engrailed-2 gene.
  118. (1998). Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III).
  119. (1990). Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain.
  120. (1986). Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries.
  121. (2000). Neurons expressing NADPH-diaphorase in the developing human spinal cord.
  122. (2010). cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
  123. (2008). Histochemical characterization, distribution and morphometric analysis of NADPH diaphorase neurons in the spinal cord of the agouti.
  124. (2003). Regulation of nitric oxide-sensitive guanylyl cyclase.
  125. (1989). Regulation of the differentiation of PC12 pheochromocytoma cells.
  126. (1997). Clinical evidence of peroxynitrite formation in chronic renal failure patients with septic shock.
  127. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.
  128. (1990). The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity.
  129. (1993). cGMP mobilizes intracellular Ca2+ in sea urchin eggs by stimulating cyclic ADP-ribose synthesis.
  130. (2002). Transient PKA activity is required for initiation but not maintenance of BDNF-mediated protection from nitric oxide-induced growth-cone collapse.
  131. (1996). Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression.
  132. (2010). The multiple actions of NO.
  133. (2004). Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
  134. (2010). New insight into the functioning of nitric oxide-receptive guanylyl cyclase: physiological and pharmacological implications.
  135. (1991). Glutamate, nitric oxide and cell-cell signalling in the nervous system.
  136. (2008). Concepts of neural nitric oxide-mediated transmission.
  137. (1989). NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.
  138. (1992). Pathway selection by ectopic motoneurons in embryonic zebrafish.
  139. (2000). Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease.
  140. (2003). Nitric oxide synthases: domain structure and alignment in enzyme function and control.
  141. (2003). Regulation of neuronal proliferation and differentiation by nitric oxide.
  142. (2001). Regulation of ventral spinal cord development in zebrafish by nitric oxide and cyclic GMP.
  143. (2001). Soluble guanylate cyclase is required during development for visual system function in Drosophila.
  144. (1998). Nitric oxide and cyclic GMP regulate retinal patterning in the optic lobe of Drosophila.
  145. (2008). Distribution of NADPH-diaphorase and nitric oxide synthase reactivity in the central nervous system of the goldfish (Carassius auratus).
  146. (1994). Expression of mouse brain soluble guanylyl cyclase and NO synthase during ontogeny.
  147. (2007). Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction.
  148. (2003). The role of nitric oxide signaling in the formation of the neuromuscular junction.
  149. (1998). Serotonin regulation of neurite outgrowth in identified neurons from mature and embryonic Helisoma trivolvis.
  150. (2005). Distribution of nitric oxide synthase immunoreactivity in the mouse brain.
  151. (1996). Fishing for genes controlling development.
  152. (1998). Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes.
  153. (1995). Nitric oxide synthases: properties and catalytic mechanism.
  154. (2003). The motor infrastructure: from ion channels to neuronal networks.
  155. (1999). Nitric oxide synthase in skeletal muscle fibers: a signaling component of the dystrophin-glycoprotein complex.
  156. (1992). Histochemistry of NADPHdiaphorase, a marker for neuronal nitric oxide synthase, in the peripheral autonomic nervous system of the mouse.
  157. (1979). Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.
  158. (1981). Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.
  159. (2002). Headwaters of the zebrafish -- emergence of a new model vertebrate.
  160. (1989). Blockade of NMDA-receptors prevents ocularity changes in kitten visual cortex after reversed monocular deprivation.
  161. (2007). Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice.
  162. (1999). Nitric oxide synthase activity reveals an asymmetrical organization of the frog habenulae during development: A histochemical and cytoarchitectonic study from tadpoles to the mature Rana esculenta, with notes on the pineal complex.
  163. (2008). Distinct immunohistochemically defined areas in the medial amygdala in the developing and adult mouse.
  164. (2003). Distinct types of nitric oxideproducing neurons in the developing and adult mouse claustrum.
  165. (2005). The physiology and pathophysiology of nitric oxide in the brain.
  166. (2005). Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR).
  167. (1998). Nitric oxide and inflammatory bowel diseases.
  168. (2003). Nitric oxide and cyclic nucleotides are regulators of neuronal migration in an insect embryo.
  169. (1991). Disruption of retinogeniculate afferent segregation by antagonists to NMDA receptors.
  170. (2001). A confocal study of spinal interneurons in living larval zebrafish.
  171. (1994). Structural organization of the human neuronal nitric oxide synthase gene (NOS1).
  172. (2000). Laser-induced gene expression in specific cells of transgenic zebrafish.
  173. (1999). Analysis of a Zebrafish semaphorin reveals potential functions in vivo.
  174. (2001). NO, nitrotyrosine, and cyclic GMP in signal transduction.
  175. (2008). Spontaneous rhythmic activity in early chick spinal cord influences distinct motor axon pathfinding decisions.
  176. (1969). Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate.
  177. (1994). cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG.
  178. (1990). Expression of soluble guanylyl cyclase. Catalytic activity requires two enzyme subunits.
  179. (1991). Diversity of expression of engrailed-like antigens in zebrafish.
  180. (1994). Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation.
  181. (1999). Regulation of neuronal nitric-oxide synthase by calmodulin kinases.
  182. (2002). Microtubule reconfiguration during axonal retraction induced by nitric oxide.
  183. (2002). Knowing how to navigate: mechanisms of semaphorin signaling in the nervous system. Sci STKE,
  184. (2010). The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.
  185. (2005). Protein Snitrosylation: purview and parameters.
  186. (1993). Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide.
  187. (2007). Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.
  188. (2004). Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish.
  189. (2004). Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish.
  190. (2009). Semaphorin 5A is a bifunctional axon guidance cue for axial motoneurons in vivo.
  191. (2010). Collagen XIXa1 is crucial for motor axon navigation at intermediate targets.
  192. (1997). Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism.
  193. (2002). Development of axon pathways in the zebrafish central nervous system.
  194. (2006). Function of cGMPdependent protein kinases as revealed by gene deletion.
  195. (2000). Identification and distribution of nitric oxide synthase in the brain of adult zebrafish.
  196. (2004). The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish.
  197. (1997). Inhibition of nitric oxide formation by aminoguanidine: an attempt to prevent insulin-dependent diabetes mellitus.
  198. (1991). Neuronal NADPH diaphorase is a nitric oxide synthase.
  199. (2003). Nitration of tau protein is linked to neurodegeneration in tauopathies.
  200. (2005). Regulation of axon growth in vivo by activity-based competition.
  201. (1997). Synaptic plasticity: a role for nitric oxide in LTP.
  202. (1997). Biochemical characterization and histochemical localization of nitric oxide synthase in the nervous system of the snail, Helix pomatia.
  203. (1995). The neurotrophins BDNF, NT-3 and -4, but not NGF, TGF-beta 1 and GDNF, increase the number of NADPH-diaphorasereactive neurons in rat spinal cord cultures.
  204. (2008). Mechanisms underlying development of visual maps and receptive fields.
  205. (1990). Purification of soluble guanylyl cyclase from bovine lung by a new immunoaffinity chromatographic method.
  206. (2007). Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression.
  207. (2006). Islet1 and Islet2 have equivalent abilities to promote motoneuron formation and to specify motoneuron subtype identity.
  208. (1998). Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
  209. (1986). Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-haem exchange. Comparison of haem-containing and haem-deficient enzyme forms.
  210. (1987). Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
  211. (1987). Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
  212. (1982). Activation of purified guanylate cyclase by nitric oxide requires haem. Comparison of haem-deficient, haem-reconstituted and haem-containing forms of soluble enzyme from bovine lung.
  213. (1998). Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse.
  214. (1998). The role of nitric oxide and NMDA receptors in the development of motor neuron dendrites.
  215. (1994). Developmental regulation of islet-1 mRNA expression during neuronal differentiation in embryonic zebrafish.
  216. (2003). Morphological basis of nitric oxide production and its correlation with the polysialylated precursor cells in the dentate gyrus of the adult guinea pig hippocampus.
  217. (1998). Precise distribution of neuronal nitric oxide synthase mRNA in the rat brain revealed by non-radioisotopic in situ hybridization.
  218. (2001). Nitric oxide is required for the induction and heterosynaptic spread of long-term potentiation in rat cerebellar slices.
  219. (2001). Protein S-nitrosylation: a physiological signal for neuronal nitric oxide.
  220. (1998). CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.
  221. (1990). The perinatal reorganization of the innervation of skeletal muscle in mammals.
  222. (1994). Cloning, expression and in situ localization of rat intestinal cGMP-dependent protein kinase II.
  223. (1999). Nitric oxide and the proliferation of vascular smooth muscle cells.
  224. (2008). Characteristics of HCN channels and their participation in neuropathic pain.
  225. (1997). In situ hybridization: methods and applications.
  226. (2010). Temporal and spatial requirements of unplugged/MuSK function during zebrafish neuromuscular development.
  227. (2009). Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor.
  228. (2000). Nitric oxide is a downstream mediator of agrin-induced acetylcholine receptor aggregation.
  229. (1999). Nitrinergic neurons in the developing and adult human telencephalon: transient and permanent patterns of expression in comparison to other mammals.
  230. (2000). Cyclic GMP evoked calcium transients in olfactory receptor cell growth cones.
  231. (1993). Molecular evidence for nitric oxide-mediated motor neuron development.
  232. (1986). Soluble guanylate cyclase from rat lung exists as a heterodimer.
  233. (2007). Nitric oxide activates leak K+ currents in the presumed cholinergic neuron of basal forebrain.
  234. (1977). Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.
  235. (2002). Cyclic nucleotide-gated ion channels.
  236. (1996). Patterns of nitric oxide synthase at the messenger RNA and protein levels during early rat brain development.
  237. (2003). Zebrafish as an experimental model: strategies for developmental and molecular neurobiology studies.
  238. (2007). Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish.
  239. (1995). Stages of embryonic development of the zebrafish.
  240. (1998). Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis.
  241. (1994). NADPH diaphorase (nitric oxide synthase)-containing nerves in the enteropancreatic innervation: sources, co-stored neuropeptides, and pancreatic function.
  242. (1993). Localization of nitric oxide synthase in the mouse olfactory and vomeronasal system: a histochemical, immunological and in situ hybridization study.
  243. (1987). Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex.
  244. (2002). Neuronal nitric oxide synthase in the rabbit spinal cord visualised by histochemical NADPH-diaphorase and immunohistochemical NOS methods.
  245. (1994). Nitric oxide synthases in mammals.
  246. (1989). Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
  247. (2004). Nitric oxide-sensitive guanylyl cyclase: structure and regulation.
  248. (2000). Inhibition of neuronal nitricoxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells.
  249. (2005). Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy,
  250. (1993). Zebrafish primary neurons initiate expression of the LIM homeodomain protein Isl-1 at the end of gastrulation.
  251. (1997). Aggressive behavior in male mice lacking the gene for neuronal nitric oxide synthase requires testosterone.
  252. (2004). Regulation of nitric oxide and soluble guanylyl cyclase.
  253. (2002). Role of nitric oxide synthase against MPTP neurotoxicity in mice.
  254. (1996). Nitric oxide synthase is concentrated at the skeletal muscle endplate.
  255. (1990). Development of spinal neurons and tracts in the zebrafish embryo.
  256. (1996). Nitric oxide regulates cell proliferation during Drosophila development.
  257. (2009). Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey.
  258. (1992). Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.
  259. (1994). Simulation of the diffusion and reaction of endogenously produced nitric oxide.
  260. (2001). Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase.
  261. (2005). Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin.
  262. (2009). Role of protein tyrosine nitration in neurodegenerative diseases and atherosclerosis.
  263. (1998). U73122 blocked the cGMP-induced calcium release in sea urchin eggs.
  264. (2008). Post-translational modifications induced by nitric oxide (NO): implication in cancer cells apoptosis.
  265. (2009). Comparative analysis of zebrafish nos2a and nos2b genes.
  266. (1997). Synergies and coincidence requirements between NO, cGMP, and Ca2+ in the induction of cerebellar long-term depression.
  267. (1995). Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients.
  268. (1997). Absence of cerebellar long-term depression in mice lacking neuronal nitric oxide synthase.
  269. (2003). From cells to circuits: development of the zebrafish spinal cord.
  270. (1991). Nonspecific defence mechanism: the role of nitric oxide.
  271. (1993). A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.
  272. (1998). Redox modulation of the NMDA receptor by NO-related species.
  273. (1988). Function of identified motoneurones and co-ordination of primary and secondary motor systems during zebra fish swimming.
  274. (1990). The formation of terminal fields in the absence of competitive interactions among primary motoneurons in the zebrafish.
  275. (2002). Ontogeny of NADPH diaphorase/nitric oxide synthase reactivity in the brain of Xenopus laevis.
  276. (2007). Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity.
  277. (1995). Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis,
  278. (1992). Nitric oxide, a novel biologic messenger.
  279. (1995). Effects of methylene blue and LY83583 on neuronal nitric oxide synthase and NADPH-diaphorase.
  280. (2002). Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity.
  281. (2000). The role of nitric oxide in nociception.
  282. (1992). Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.
  283. (2003). NO enhances presynaptic currents during cerebellar mossy fiber-granule cell LTP.
  284. (2006). Nitric oxide regulates the proliferation of chick embryo retina cells by a cyclic GMP-independent mechanism.
  285. (1988). Motor neurons contain agrin-like molecules.
  286. (1997). Nitric oxide facilitates long-term potentiation, but not long-term depression.
  287. (2007). Regulation of apoptosis by protein S-nitrosylation.
  288. (1995). Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrance conductance regulator.
  289. (1988). Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.
  290. (2000). A short history of nitroglycerine and nitric oxide in pharmacology and physiology.
  291. (1998). Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish.
  292. (2004). S-nitrosylation: a potential new paradigm in signal transduction.
  293. (1999). Methylene blue, a soluble guanylyl cyclase inhibitor, reduces the sevoflurane minimum alveolar anesthetic concentration and decreases the brain cyclic guanosine monophosphate content in rats.
  294. (2007). Long-term depression: multiple forms and implications for brain function.
  295. (1993). Developmental changes of cytosolic and particulate nitric oxide synthase in rat brain.
  296. (2009). Stimulation of the cAMP system by the nitric oxide-cGMP system underlying the formation of long-term memory in an insect.
  297. (1993). Inhibition of nitric oxide synthesis by methylene blue.
  298. (1993). Novel actions of methylene blue.
  299. Roles for gamma-aminobutyric acid in the development of the paraventricular nucleus of the hypothalamus.
  300. (1997). Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis.
  301. (2004). Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish.
  302. (2008). Using imaging and genetics in zebrafish to study developing spinal circuits in vivo.
  303. (2009). Spinal interneurons differentiate sequentially from those driving the fastest swimming movements in larval zebrafish to those driving the slowest ones.
  304. (2001). Induction of a non-rhythmic motor pattern by nitric oxide in hatchling Rana temporaria embryos.
  305. (2000). The distribution of NADPH-diaphorase-labelled interneurons and the role of nitric oxide in the swimming system of Xenopus laevis larvae.
  306. (2001). Spatiotemporal pattern of nicotinamide adenine dinucleotide phosphate-diaphorase reactivity in the developing central nervous system of premetamorphic Xenopus laevis tadpoles.
  307. (2002). Nitric oxide selectively tunes inhibitory synapses to modulate vertebrate locomotion.
  308. (2004). Metamodulation of a spinal locomotor network by nitric oxide.
  309. (1997). Pathfinding by identified zebrafish motoneurons in the absence of muscle pioneers.
  310. (1993). Nitric oxide (NO) and nociceptive processing in the spinal cord.
  311. (1986). Development of reticulospinal neurons of the zebrafish. II. Early axonal outgrowth and cell body position.
  312. (2008). Embryonic motor activity and implications for regulating motoneuron axonal pathfinding in zebrafish.
  313. (1993). Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel.
  314. (1999). Targeting and translocation of endothelial nitric oxide synthase.
  315. (2009). Nitric oxide and pain: 'Something old, something new'.
  316. (2001). Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure.
  317. (1998). The role of nitric oxide in development of the patch-cluster system and retinocollicular pathways in the rodent superior colliculus.
  318. (1995). Nitric oxide in inflammation and immune response.
  319. (1998). The role of nitric oxide in neurodegeneration. Potential for pharmacological intervention.
  320. (2006). The discovery of nitric oxide and its role in vascular biology.
  321. (2000). Morphological bases for a role of nitric oxide in adult neurogenesis.
  322. (2001). Modulation of Kv3 potassium channels expressed in CHO cells by a nitric oxideactivated phosphatase.
  323. (2002). Early development of NADPH diaphorase-expressing neurons in the brain of the urodele amphibian Pleurodeles waltl.
  324. (2010). Developmental regulation of subtype-specific motor neuron excitability.
  325. (2004). Nitric oxide regulates swimming in the jellyfish Aglantha digitale.
  326. (2000). Prolonged activation of cAMP-dependent protein kinase during conditioning induces long-term memory in honeybees.
  327. (2002). Nitric oxide/cGMP-mediated protein kinase A activation in the antennal lobes plays an important role in appetitive reflex habituation in the honeybee.
  328. (2000). Localization of NADPH diaphorase/nitric oxide synthase and choline acetyltransferase in the spinal cord of the frog, Rana perezi.
  329. (2010). Nitric oxide and cancer.
  330. (2003). Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected].
  331. (2002). Therapeutic effect of neuronal nitric oxide synthase inhibitor (7-nitroindazole) against MPTP neurotoxicity in mice.
  332. (2003). Developing patterns of nitric oxide synthesizing neurons in the rat striatum: histochemical analysis.
  333. (2003). Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb.
  334. (2001). Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle.
  335. (1985). Spinal motoneurons of the larval zebrafish.
  336. (1986). Development and axonal outgrowth of identified motoneurons in the zebrafish.
  337. (1987). A cyclic nucleotide-gated conductance in olfactory receptor cilia.
  338. (2005). Identification of a conserved 125 base-pair Hb9 enhancer that specifies gene expression to spinal motor neurons.
  339. (2000). Effective targeted gene 'knockdown' in zebrafish.
  340. (2004). Distribution of choline acetyltransferase and NADPH diaphorase in the spinal cord of the pigeon.
  341. (2005). Embryonic development of choline acetyltransferase and nitric oxide synthase in the spinal cord of pigeons and chickens with special reference to the superficial dorsal horn.
  342. (2007). Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
  343. (2003). Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning.
  344. (1998). Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures.
  345. (1997). Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes.
  346. (1996). Neuronal nitric oxide synthase (nNOS) mRNA expression and NADPH-diaphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer's disease brains.
  347. (1996). Nitric oxide synthase 1 and nitric oxide synthase 3 protein expression is regionally and temporally regulated in fetal brain.
  348. (2009). PKG and PKA signaling in LTP at GABAergic synapses.
  349. (1991). Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
  350. (1999). Differential maturational patterns of nitric oxide synthase-I and NADPH diaphorase in functionally distinct cortical areas of the mouse cerebral cortex.
  351. (1979). Methemoglobin blockade of coronary arterial soluble guanylate cyclase activation by nitroso compounds and its reversal with dithiothreitol.
  352. (1968). Frame shift mutations near the beginning of the lysozyme gene of bacteriophage T4.
  353. (2005). Distribution of nitric oxide-producing neurons in the developing and adult mouse amygdalar basolateral complex.
  354. (2008). Development of enteric and vagal innervation of the zebrafish (Danio rerio) gut.
  355. (2001). Function of Neurolin (DMGRASP/SC-1) in guidance of motor axons during zebrafish development.
  356. (1999). NADPH diaphorase histochemistry in the thoracic ganglia of locusts, crickets, and cockroaches: species differences and the impact of fixation.
  357. (2007). Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance.
  358. (1988). Vascular endothelial cells synthesize nitric oxide from L-arginine.
  359. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor.
  360. (1988). L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation.
  361. (2006). Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms.
  362. (2005). Neuromuscular synaptogenesis in wild-type and mutant zebrafish.
  363. (2006). In vivo imaging of preferential motor axon outgrowth to and synaptogenesis at prepatterned acetylcholine receptor clusters in embryonic zebrafish skeletal muscle.
  364. (1998). Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse.
  365. (2000). Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons.
  366. (2002). olig2 is required for zebrafish primary motor neuron and oligodendrocyte development.
  367. (1998). Anterograde signaling by nitric oxide: characterization and in vitro reconstitution of an identified nitrergic synapse.
  368. (2006). Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects.
  369. (2005). NO as a mediator during the early development of the cardiovascular system in the zebrafish.
  370. (1995). Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells.
  371. (2001). Nitric oxide is an essential negative regulator of cell proliferation in Xenopus brain.
  372. (2007). Nitric oxide coordinates cell proliferation and cell movements during early development of Xenopus.
  373. (1996). Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.
  374. (1999). Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: a cGMP independent pathway.
  375. (1999). Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets.
  376. (1990). Identified primary motoneurons in embryonic zebrafish select appropriate pathways in the absence of other primary motoneurons.
  377. (1992). Pathfinding by zebrafish motoneurons in the absence of normal pioneer axons.
  378. (2002). Patterning of the vertebrate ventral spinal cord.
  379. (2008). Expression of zebrafish nos2b surrounds oral cavity.
  380. (2003). Expression pattern of neuronal nitric oxide synthase in embryonic zebrafish.
  381. (1999). Mechanism of superoxide generation by neuronal nitric-oxide synthase.
  382. (1996). Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
  383. (1995). Diversity in localisation of nitric oxide synthase antigen and NADPH-diaphorase histochemical staining in sacral somatic motor neurones of the cat.
  384. (2007). GTPases in semaphorin signaling.
  385. (2005). Soluble guanylyl cyclase: more secrets revealed.
  386. (1995). Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
  387. (1987). The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium.
  388. (1990). An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.
  389. (2007). Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP.
  390. (2006). Developmental and regional expression of NADPH-diaphorase/nitric oxide synthase in spinal cord neurons correlates with the emergence of limb motor networks in metamorphosing Xenopus laevis.
  391. (2004). Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor.
  392. (2007). Biphasic coupling of neuronal nitric oxide synthase phosphorylation to the NMDA receptor regulates AMPA receptor trafficking and neuronal cell death.
  393. (2008). Active and inactive pools of nNOS in the nerve terminals in mouse gut: implications for nitrergic neurotransmission.
  394. (2007). LTP forms 1, 2 and 3: different mechanisms for the "long" in long-term potentiation.
  395. (2005). Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure.
  396. (2008). Development and adult organization of the lateral part of the bed nucleus of the stria terminalis in the chicken.
  397. (1996). Inhibition of nitric oxide synthase does not alter ocular dominance shifts in kitten visual cortex.
  398. (1996). Exogenous nitric oxide causes collapse of retinal ganglion cell axonal growth cones in vitro.
  399. (2004). Slow degeneration of zebrafish Rohon-Beard neurons during programmed cell death.
  400. (2001). Roles for nitric oxide and arachidonic acid in the induction of heterosynaptic cerebellar LTD.
  401. (2000). Nitric oxide mediates laminin-induced neurite outgrowth in PC12 cells.
  402. (1998). Nitric oxide synthase in rat neuromuscular junctions and in nerve terminals of Torpedo electric organ: its role as regulator of acetylcholine release.
  403. (1995). Developmental changes of NADPHdiaphorase neurons in the forebrain of neonatal and adult cat.
  404. (2001). Nitric oxide-dependent apoptosis in ovarian carcinoma cell lines.
  405. (2005). Drosophila soluble guanylyl cyclase mutants exhibit increased foraging locomotion: behavioral and genomic investigations.
  406. (2004). Zebrafish topped is required for ventral motor axon guidance.
  407. (1999). Phosphorylation of tyrosine hydroxylase by cGMP-dependent protein kinase in intact bovine chromaffin cells.
  408. (2008). Age-dependent effect of nitric oxide on subventricular zone and olfactory bulb neural precursor proliferation.
  409. (1999). Zebrafish semaphorin Z1b inhibits growing motor axons in vivo.
  410. (1994). Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons.
  411. (1992). Axonogenesis and morphogenesis in the embryonic zebrafish brain.
  412. (2008). An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase.
  413. (2004). Nitric oxide, an iceberg in cardiovascular physiology: far beyond vessel tone control.
  414. (2001). Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes.
  415. (1996). Inhibition of nitric oxide synthase does not prevent ocular dominance plasticity in kitten visual cortex.
  416. (2002). Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells.
  417. (2006). Development of motor networks in zebrafish embryos.
  418. (1998). Time course of the development of motor behaviors in the zebrafish embryo.
  419. (2000). Motoneuron activity patterns related to the earliest behavior of the zebrafish embryo.
  420. (2001). Synchronization of an embryonic network of identified spinal interneurons solely by electrical coupling.
  421. (1994). Rat spinal cord neurons contain nitric oxide synthase.
  422. (2004). NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity.
  423. (1988). Identification of arginine as a precursor of endothelium-derived relaxing factor.
  424. (1995). Expression of NADPH-diaphorase in the rat forebrain during development.
  425. (1999). Development of the vertebrate neuromuscular junction.
  426. (2009). Many paths to synaptic specificity.
  427. (1998). Expression of neuronal nitric oxide synthase during embryonic development of the rat cerebral cortex.
  428. (2000). iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis.
  429. (2006). Sema3a1 guides spinal motor axons in a cell- and stage-specific manner in zebrafish.
  430. (2009). Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish.
  431. (1999). Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.
  432. (1997). Cyclic-nucleotide-gated channels mediate synaptic feedback by nitric oxide.
  433. (1999). Failure to disrupt development of cholinergic fiber patches in the superior colliculus in nitric oxide synthase deficient mice.
  434. (2001). Prenatal and postnatal expression of nitric oxide in the developing kitten superior colliculus revealed with NADPH diaphorase histochemistry.
  435. (2003). Approaches for the sequence-specific knockdown of mRNA.
  436. (2009). The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
  437. (1988). Arginine is a physiological precursor of endothelium-derived nitric oxide.
  438. (2009). No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing.
  439. (2006). The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migration.
  440. (1994). NADPH-diaphorase in the central nervous system of the larval lamprey (lampetra planeri).
  441. (1995). Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.
  442. (2004). Nitric oxide synthase activity is required for postsynaptic differentiation of the embryonic neuromuscular junction.
  443. (2005). Tenascin-C is involved in motor axon outgrowth in the trunk of developing zebrafish.
  444. (2000). Nitric oxide and cGMP influence axonogenesis of antennal pioneer neurons.
  445. (1992). Relaxation of pig coronary arteries by new and potent cGMP analogues that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase.
  446. (2002). Regulation of endothelial nitric oxide synthase: location, location, location.
  447. (2008). Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection.
  448. (2001). Functional analysis of zebrafish GDNF.
  449. (1993). Cerebellar long-term depression enabled by nitric oxide, a diffusible intercellular messenger.
  450. (1991). Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum.
  451. (1998). Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and haem groups located on adjacent subunits in the dimer.
  452. (1996). Neuronal nitric-oxide synthase-mu, an alternatively spliced isoform expressed in differentiated skeletal muscle.
  453. (1996). Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease.
  454. (1997). Distribution of NADPH-diaphorase and nitric oxide synthase in relation to catecholaminergic neuronal structures in the brain of the lizard Gekko gecko.
  455. (1992). Nitric oxide: first in a new class of neurotransmitters.
  456. (1991). Nitric oxide as a neuronal messenger.
  457. (1991). Nitric oxide. New discoveries, biomedical implications.
  458. (1998). Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.
  459. (2008). Protein tyrosine nitration--functional alteration or just a biomarker? Free Radic
  460. (1993). Coexistence of NADPH diaphorase with GABA, glycine, and acetylcholine in rat spinal cord.
  461. (2001). Physiology of nitric oxide in skeletal muscle.
  462. (2008). Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse.
  463. (1995). Interaction of calmodulin with the inducible murine macrophage nitric oxide synthase.
  464. (1987). Reversal of acetylcholine-induced coronary resistance vessel dilation by hemoglobin.
  465. (2000). Nitric oxide indices in human septic shock.
  466. (1966). Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday. Cold Spring Harb Symp Quant
  467. (1986). Segregation analyses and gene-centromere distances in zebrafish.
  468. (1981). Production of clones of homozygous diploid zebra fish (Brachydanio rerio).
  469. (2007). S-Nitrosylation of microtubuleassociated protein 1B mediates nitric-oxide-induced axon retraction.
  470. (2005). Distribution of GABA, calbindin and nitric oxide synthase in the developing chick entopallium.
  471. (1993). Phosphorylation of serine 2843 in ryanodine receptor-calcium release channel of skeletal muscle by cAMP-, cGMP- and CaM-dependent protein kinase.
  472. (2005). Nitric-oxidedirected synaptic remodeling in the adult mammal CNS.
  473. (2007). The role of reactive oxygen species and nitric oxide in mast cell-dependent inflammatory processes.
  474. (1991). Regulation of the cardiac ryanodine receptor by protein kinase-dependent phosphorylation.
  475. (1996). NADPH-diaphorase in the developing rat: lower brainstem and cervical spinal cord, with special reference to the trigemino-solitary complex.
  476. (2008). The Met receptor tyrosine kinase prevents zebrafish primary motoneurons from expressing an incorrect neurotransmitter.
  477. (1994). Roles of endogenous nitric oxide in cerebellar cortical development in slice cultures.
  478. (2004). Differential roles of neuronal and endothelial nitric oxide synthases during carrageenan-induced inflammatory hyperalgesia.
  479. (2009). More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation.
  480. (2009). Nitric oxide and cGMP signal transduction positively regulates the motility of human neuronal precursor (NT2) cells.
  481. (2010). Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci.
  482. (2005). New ways to admire zebrafish: progress in functional genomics research methodology.
  483. (1996). Morphology of NADPHdiaphorase-positive cells in the retinoceptive layers of the developing rat superior colliculus.
  484. (1996). Distribution of nitric oxide synthase-immunoreactive neurons in fetal rat brains at embryonic day 15 and day 19.
  485. (2001). Ontogenesis of neurons immunoreactive for nitric oxide synthase in rat forebrain and midbrain.
  486. (1993). Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat.
  487. (2001). Differential frequency-dependent regulation of transmitter release by endogenous nitric oxide at the amphibian neuromuscular synapse.
  488. (1998). nNOS expressing neurons in the entorhinal cortex and hippocampus are affected in patients with Alzheimer's disease.
  489. (2004). Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions.
  490. (2004). Protein kinase G type II is required for night-to-day progression of the mammalian circadian clock.
  491. (2008). Cyclic GMP-gated CNG channels function in Sema3A-induced growth cone repulsion.
  492. (2009). The nitric oxide-cGMP pathway controls the directional polarity of growth cone guidance via modulating cytosolic Ca2+ signals.
  493. (1995). Molecular heterogeneity among primary motoneurons and within myotomes revealed by the differential mRNA expression of novel islet-1 homologs in embryonic zebrafish.
  494. (2007). Nitric oxide release from a single cell affects filopodial motility on growth cones of neighboring neurons.
  495. (1993). Nitric oxide synthases in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity.
  496. (2004). Nitric oxide acts as a slow-down and search signal in developing neurites.
  497. (2007). The role of nitric oxide in inflammatory reactions.
  498. (1996). Nitric oxide-sensitive guanylate cyclase activity is associated with the maturational phase of neuronal development in insects.
  499. (2009). Oxidative and nitrosative stress in Parkinson's disease.
  500. (2004). Homeostatic plasticity in the developing nervous system.
  501. (2008). Atherosclerosis: A Link Between Lipid Intake and Protein Tyrosine Nitration. Lipid Insights,
  502. (2001). L-NAME precipitates catatonia during ethanol withdrawal in rats.
  503. (2000). Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colon .
  504. (1982). Differentiation of muscle fiber types in the teleost Brachydanio rerio, the zebrafish. Posthatching development.
  505. (1999). Regulation of neuronal growth cone filopodia by nitric oxide.
  506. (2001). Regulation of neuronal growth cone filopodia by nitric oxide depends on soluble guanylyl cyclase.
  507. (1998). Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.
  508. (1999). Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer.
  509. (2006). Nitric oxide and cell proliferation.
  510. (1999). Development of NADPH-diaphorase activity in the central nervous system of the cichlid fish, Tilapia mariae.
  511. (2001). The development of NADPHdiaphorase and nitric oxide synthase in the visual system of the cichlid fish, Tilapia mariae.
  512. (2010). Nitric oxide neurons and neurotransmission.
  513. (2001). Regional distribution of nitric oxide synthase and NADPH-diaphorase activities in the central nervous system of teleosts.
  514. (1998). Role of cGMP-kinase II in the control of renin secretion and renin expression.
  515. (1995). Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses.
  516. (2004). FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.
  517. (2003). Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase.
  518. (2004). Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance.
  519. (2005). Local activation of the nitric oxide/cyclic guanosine monophosphate pathway in growth cones regulates filopodial length via protein kinase G, cyclic ADP ribose and intracellular Ca2+ release.
  520. (2007). Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release.
  521. (1994). The Zebrafish Book: a Guide to the Laboratory Use of the Zebrafish (Brachydanio rerio),
  522. (1986). Identified motoneurons and their innervation of axial muscles in the zebrafish.
  523. (1995). Transient and continuous expression of NADPH diaphorase in different neuronal populations of developing rat spinal cord.
  524. (1994). Choline acetyltransferase and NADPH diaphorase are coexpressed in rat spinal cord neurons.
  525. (1999). Nitric oxide and cyclic GMP induce vesicle release at Drosophila neuromuscular junction.
  526. (1994). Correlation of nitric oxide synthase expression with changing patterns of axonal projections in the developing visual system.
  527. (2002). The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain.
  528. (1996). Nitric oxide-induced mobilization of intracellular calcium via the cyclic ADP-ribose signaling pathway.
  529. (1995). Identification of sequences mediating guanylyl cyclase dimerization.
  530. (2005). Expression of nitric oxide synthase isoforms is reduced in late-gestation ovine fetal brainstem.
  531. (1994). Models of the diffusional spread of nitric oxide: implications for neural nitric oxide signalling and its pharmacological properties.
  532. (2000). Refinement of the ipsilateral retinocollicular projection is disrupted in double endothelial and neuronal nitric oxide synthase gene knockout mice.
  533. (2000). Normal development of the ipsilateral retinocollicular pathway and its disruption in double endothelial and neuronal nitric oxide synthase gene knockout mice.
  534. (2001). The role of nitric oxide in development of topographic precision in the retinotectal projection of chick.
  535. (1994). Involvement of nitric oxide in the elimination of a transient retinotectal projection in development.
  536. (2002). Regulation of endothelial nitric oxide synthase activity and gene expression.
  537. (2009). Optogenetic dissection of a behavioural module in the vertebrate spinal cord.
  538. (1996). Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.
  539. (1992). Cloning and characterization of inducible nitric oxide synthase from mouse macrophages.
  540. (2007). Embryonic motor neuron dendrite growth is stunted by inhibition of nitric oxide-dependent activation of soluble guanylyl cyclase and protein kinase G.
  541. (2004). Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals.
  542. (2000). Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase.
  543. (2006). Nitric oxide/cyclic guanosine monophosphate-mediated growth cone collapse of dentate granule cells.
  544. (2008). Longrange axonal calcium sweep induces axon retraction.
  545. (2005). Fundamental role of nitric oxide in neuritogenesis of PC12h cells.
  546. (2006). Differences in neuritogenic response to nitric oxide in PC12 and PC12h cells.
  547. (2001). Activation of the mitogenactivated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells.
  548. (2004). Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells.
  549. (1997). Immunolocalization of nitric oxide synthases at the postsynaptic domain of human and rat neuromuscular junctions--light and electron microscopic studies.
  550. (1999). The zebrafish diwanka gene controls an early step of motor growth cone migration.
  551. (2002). Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues.
  552. (2000). The zebrafish unplugged gene controls motor axon pathway selection.
  553. (2004). Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice.
  554. (2001). A dual role for the zebrafish unplugged gene in motor axon pathfinding and pharyngeal development.
  555. (2001). Electrical activity and development of neural circuits.
  556. (2004). Nitric oxide synthase inhibition prevents neuronal death in the developing visual cortex.
  557. (2002). Developmental expression and activity variation of nitric oxide synthase in the brain of golden hamster.
  558. (2007). Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder.
  559. (2009). Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications.
  560. (2008). Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.