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The Molecular Interactions between Filtered Proteins and Proximal Tubular Cells in Proteinuria

By Richard J. Baines and Nigel J. Brunskill

Abstract

Proteinuria is associated with progressive chronic kidney disease and poor cardiovascular outcomes. Exposure of proximal tubular epithelial cells to excess proteins leads to the development of proteinuric nephropathy with tubular atrophy, interstitial inflammation and scarring. Numerous signalling pathways are activated in proximal tubular epithelial cells under proteinuric conditions resulting in gene transcription, altered growth and the secretion of inflammatory and profibrotic mediators. Megalin, the proximal tubular scavenger receptor for filtered macromolecules, has intrinsic signalling functions and may also link albumin to growth factor receptor signalling via regulated intramembrane proteolysis. It now seems that endocytosis is not always a prerequisite for albumin-evoked alterations in proximal tubular cell phenotype. Recent evidence shows the presence of other potential receptors for proteins, such as the neonatal Fc receptor and CD36, in the proximal tubular epithelium

Publisher: Karger
Year: 2008
DOI identifier: 10.1159/000161982
OAI identifier: oai:lra.le.ac.uk:2381/8871
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  1. (2005). Albumin activates ERK via EGF receptor in human renal epithelial cells.
  2. (2007). Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury. doi
  3. (2000). EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. doi
  4. (1996). Expression of epidermal growth factor and its receptor in normal and diseased human kidney: An immunohistochemical and in situ hybridization study. Kidney Int doi
  5. (2006). Perspective – FcRn transports albumin: relevance to immunology and medicine. Trends Immunol doi
  6. (2008). Podocytes use FcRn to clear IgG from the glomerular basement membrane. doi
  7. (2008). Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis. doi
  8. (2008). The C-terminus of megalin regulates gene expression in opossum kidney proximal tubule (OKP) cells. doi
  9. (2007). The role played by endocytosis in albumin-induced secretion of TGFβ-1 by proximal tubular epithelial cells. doi

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