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Length and Distribution of Meiotic Gene Conversion Tracts and Crossovers in Saccharomyces cerevisiae

By Rhona H. Borts and James E. Haber

Abstract

The full-text of this article is not available on the LRA. The original published version can be found on the publisher's website at: http://www.genetics.org/We have measured gene conversion tract length in strains of the yeast Saccharomyces cerevisiae\ud containing three to six restriction site heterozygosities in a 9-kb interval. Tetrads containing a\ud conversion were identified genetically by nonmendelian segregation of a marker in the middle of the\ud interval. Gene conversions accompanied by a crossover have a tract length of 1.4 kb ± 0.7 kb, which\ud is indistinguishable from a tract length of 1.6 ± 0.8 for conversions without an associated exchange.\ud Among tetrads identified first as having a crossover in the interval, the average gene conversion tracts\ud were apparently significantly shorter (0.71 ± 1). We provide evidence that this apparent difference is\ud due to the method of measuring conversion tracts and does not reflect a real difference in tract\ud length. We also provide evidence that the number and position of restriction site markers alters the\ud apparent distribution of the conversion tracts. More than ninety percent of the conversion tracts\ud spanning three or more sites were continuou

Publisher: Genetics Society of America
Year: 1989
OAI identifier: oai:lra.le.ac.uk:2381/8799
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