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Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G·C·G·C tetrad

By Kah Wai Lim, Patrizia Alberti, Aurore Guédin, Laurent Lacroix, Jean-François Riou, Nicola J. Royle, Jean-Louis Mergny and Anh Tuân Phan

Abstract

Short contiguous arrays of variant CTAGGG repeats in the human telomere are unstable in the male germline and somatic cells, suggesting formation of unusual structures by this repeat type. Here, we report on the structure of an intramolecular G-quadruplex formed by DNA sequences containing four human telomeric variant CTAGGG repeats in potassium solution. Our results reveal a new robust antiparallel G-quadruplex fold involving two G-tetrads sandwiched between a G·C base pair and a G·C·G·C tetrad, which could represent a new platform for drug design targeted to human telomeric DNA

Publisher: Oxford University Press (OUP)
Year: 2009
DOI identifier: 10.1093/nar
OAI identifier: oai:lra.le.ac.uk:2381/8486
Journal:

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