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Molecular properties of P2X receptors

By Jonathan A. Roberts, Catherine Vial, Helen R. Digby, Kelvin C. Agboh, Hairuo Wen, Amelia Atterbury-Thomas and Richard J. Evans

Abstract

This paper was published as Pflügers Archiv European Journal of Physiology, 2006, 452 (5), pp. 486-500. It is available from http://www.springerlink.com/content/12h8458178x57955/. Doi: 10.1007/s00424-006-0073-6Metadata only entryP2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation channels with two transmembrane domains, intracellular amino and carboxy termini and a large extracellular ligand binding loop. Seven genes (P2X1-7) have been cloned and the channels form as either homo or heterotrimeric channels giving rise to a wide range of phenotypes. This review aims to give an account of recent work on the molecular basis of the properties of P2X receptors. In particular, to consider emerging information on the assembly of P2X receptor subunits, channel regulation and desensitisation, targeting, the molecular basis of drug action and the functional contribution of P2X receptors to physiological processes

Publisher: Springer Berlin / Heidelberg
Year: 2006
DOI identifier: 10.1007/s00424-006-0073-6
OAI identifier: oai:lra.le.ac.uk:2381/8047
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