Skip to main content
Article thumbnail
Location of Repository

ß-defensins and Crohn's disease: confusion from counting copies

By Edward J. Hollox

Abstract

Recent research has suggested that a family of antimicrobial and inflammatory molecules, called β-defensins, are involved in the etiology of Crohn's disease. In this issue, Bentley and colleagues provide data that disagree with previous studies. They show that the β-defensins that are copy number polymorphic have, on average, higher genomic copy number in patients when compared with healthy controls. This editorial places these new data in the context of previous research on the genetics of β-defensin copy number polymorphism and association with Crohn's disease. It also suggests a path allowing this research area to move forward with confidence

Publisher: Nature Publishing Group
Year: 2009
DOI identifier: 10.1038/ajg.2009.573
OAI identifier: oai:lra.le.ac.uk:2381/8033
Journal:

Suggested articles

Citations

  1. (2006). A chromosome 8 genecluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. doi
  2. (1997). Alpha 1-antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E epsilon 4 allele carriers. doi
  3. (1996). Alpha 1-antichymotrypsin gene polymorphism and risk for Alzheimer's disease. doi
  4. (2009). Association of higher DEFB4 genomic copy number with Crohn's disease. doi
  5. (2009). Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin. doi
  6. (2009). Defensins and inflammation: the role of defensins in inflammatory bowel disease. doi
  7. (2008). Defensins and the dynamic genome: what we can learn from structural variation at human chromosome band 8p23.1. doi
  8. (2009). Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease. PLoS One 4:e6285 doi
  9. (2003). Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. doi
  10. Nicolae DL and 61 co-authors (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
  11. (2006). NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. doi
  12. (2005). Population structure, differential bias and genomic control in a large-scale, case-control association study. doi
  13. (2000). Role of smoking in inflammatory bowel disease: implications for therapy.
  14. The AlzGene Database. Alzheimer Research Forum. Available at: http://www.alzgene.org. doi
  15. (2009). The genetics of Crohn's disease. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.