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Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis

By A.L. Koekemoer, N.W. Chong, A.H. Goodall and N.J. Samani


This is the author’s final draft post-refereeing of FEBS Letters 583 (2009) 2964-2967. Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis. Andrea L. Koekemoer, Nelson W. Chong, Alison H. Goodall, Nilesh J. Samani. The final published version is available at the DOI below:Myocyte stress 1 (MS1) is a recently described striated muscle actin-binding protein that is up-regulated in the early stages of pressure overload left ventricular hypertrophy. The aim of this study was to determine whether MS1 induces cellular hypertrophy and protects against apoptosis. Over-expressed MS1 co-localized with actin in H9c2 cells and altered expression of genes of the myocardin-related transcription factor (MRTF)/serum response factor (SRF) transcriptional pathways and in addition the apoptosis repressor with caspase recruitment domain (Nol3) gene. The size of cells over-expressing MS1 was significantly increased by 55% and over-expression of MS1 dramatically inhibited staurosporine-induced apoptosis by 89%. These findings suggest the involvement of MS1 in cellular hypertrophy and protection against apoptosis

Topics: MS1, Hypertrophy, Apoptosis, NOL3, MRTF, SRF, STARS
Publisher: Elsevier
Year: 2009
DOI identifier: 10.1016/j.febslet.2009.08.011
OAI identifier:

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