This paper was published as Seminars in Cell & Developmental Biology, 2006, 17 (3), pp. 363-376. It is available from http://www.sciencedirect.com/science/journal/10849521. Doi: 10.1016/j.semcdb.2006.03.005Metadata only entryRegulators of G-protein signalling (RGS) proteins are a large and diverse family initially identified as GTPase activating proteins (GAPs) of heterotrimeric G-protein Gα-subunits. At least some can also influence Gα activity through either effector antagonism or by acting as guanine nucleotide dissociation inhibitors (GDIs). As our understanding of RGS protein structure and function has developed, so has the realisation that they play roles beyond G-protein regulation. Such diversity of function is enabled by the variety of RGS protein structure and their ability to interact with other cellular molecules including phospholipids, receptors, effectors and scaffolds. The activity, sub-cellular distribution and expression levels of RGS proteins are dynamically regulated, providing a layer of complexity that has yet to be fully elucidated
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