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Properdin Deficiency in Murine Models of Non-Septic Shock

By Nina D. Ivanovska, Petya A. Dimitrova, Jeni C. Luckett, Rana El-Rachkidy Lonnen, Wilhelm J. Schwaeble and Cordula M. Stover

Abstract

This article was published as Journal of Immunology, 2008, 180, pp. 6962-6969. Copyright © 2008 American Association of Immunologists. It is available from http://www.jimmunol.org/.Hereditary properdin deficiency is linked to susceptibility to meningococcal disease (Neisseria meningitidis serotypes Y and W-135) with high mortality. Its relative contribution toward the outcome of nonseptic shock has not been investigated. Using properdin-deficient C57BL/6 mice and their littermates, this study examines their survival of zymosan-induced and LPS-induced shock. Properdin-deficient mice were more resistant to zymosan shock compared with wild-type mice, which showed greater impairment of end-organ function 24 h after zymosan injection, higher TNF-α production by alveolar and peritoneal macrophages, higher TNF-α, and, inversely, lower IL-10 levels in peritoneal lavage and circulation and higher plasma C5a levels. Properdin-deficient mice showed significantly higher mortality in LPS shock, elevated TNF-α, and, inversely, reduced IL-10 production by peritoneal macrophages as well as lower plasma C5a levels compared with wild-type littermates. NO production by peritoneal macrophages and plasma 1-antitrypsin levels at 24 h after the injection of LPS or zymosan were decreased in properdin-deficient mice in both models, and fewer histopathologic changes in liver were observed in properdin-deficient animals. This study provides evidence that properdin deficiency attenuates zymosan-induced shock and exacerbates LPS-induced shock

Publisher: American Association of Immunologists
Year: 2008
OAI identifier: oai:lra.le.ac.uk:2381/4033
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