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Directed DNA Metallization

By G. A. Burley, J. Gierlich, M. R. Mofid, H. Nir, S. Tal, Y. Eichen and T. Carell

Abstract

Genes of interest can be selectively metallized via the incorporation of modified triphosphates. These triphosphates bear functions that can be further derivatized with aldehyde groups via the use of click chemistry. Treatment of the aldehyde-labeled gene mixture with the Tollens reagent, followed by a development process, results in the selective metallization of the gene of interest in the presence of natural DNA strands

Year: 2006
DOI identifier: 10.1021/ja055517v
OAI identifier: oai:lra.le.ac.uk:2381/577
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