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Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms.

By Miranda Johnson, A. Cockayne, Peter H. Williams and Julie A. Morrissey


We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron.Peer-reviewedPublisher Versio

Publisher: American Society for Microbiology.
Year: 2005
DOI identifier: 10.1128/JB.187.23.8211-8215.2005
OAI identifier:

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