Skip to main content
Article thumbnail
Location of Repository

The pathogenic role of IgA1 0-linked glycosyation in the pathogenesis of IgA nephropathy

By Jonathan Barratt, Alice C. Smith and John Feehally


This the author's final draft version of the article published as Nephrology, 2007, 12 (3), 275-284. The published version can be accessed at

Publisher: Blackwell
Year: 2007
OAI identifier:

Suggested articles


  1. (1987). A: Immune response to oral polio vaccine in patients with IgA glomerulonephritis.
  2. (2003). AC: Beta-1-3-galactosyltransferase activity in IgA nephropathy. doi
  3. (1999). AC: Exaggerated systemic antibody response to mucosal Helicobacter pylori infection in IgA nephropathy. doi
  4. (1985). AL: Cell biology of the asialoglycoprotein receptor system: a model of receptormediated endocytosis. Int Rev Cytol 97:47-95, doi
  5. (1996). Bake AW: Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy. Kidney Int 50:952-961, doi
  6. (1999). Basic immunology: glycosylation of immunoglobulin A influences its receptor binding [In Process Citation]. doi
  7. (2007). Development of Immunoglobulin A Nephropathy- Like Disease in {beta}-1,4-Galactosyltransferase-I-Deficient Mice. doi
  8. (2003). Different glycosylation profile of serum IgA1 in IgA nephropathy according to the glomerular basement membrane thickness: normal versus thin. doi
  9. (2006). DJ: Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. doi
  10. (1996). EC: A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. Comparison with vascular cell adhesion molecule-1 and correlation with beta 7 integrins and memory differentiation.
  11. (1999). Es LA: Decreased IgA1 response after primary oral immunization with live typhoid vaccine in primary IgA nephropathy. Nephrol Dial Transplant 14:353-359, doi
  12. (1994). Expression of J chain mRNA in duodenal IgA plasma cells in IgA nephropathy. doi
  13. (2005). Fan JM: Peripheral B lymphocyte beta1,3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy. doi
  14. (1982). FW: Complete amino acid sequence of the delta heavy chain of human immunoglobulin D. doi
  15. (2006). H: A mutant chaperone converts a wild-type protein into a tumor-specific antigen. Science 314:304-308, doi
  16. (2003). Homing Receptor Expression of doi
  17. Increased and prolonged production of specific polymeric IgA after systemic immunization doi
  18. (1996). Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA. doi
  19. (2001). KN: Charge-dependent binding of polymeric IgA1 to human mesangial cells in IgA nephropathy. doi
  20. (2000). Lelievre E: Structural and functional properties of membrane and secreted IgD. Mol Immunol 37:871-887, doi
  21. (1997). Leucocyte beta 1,3 galactosyltransferase activity in IgA nephropathy. doi
  22. (1994). Low antibody affinity restricted to the IgA isotype in IgA nephropathy. Clin Exp Immunol 95:35-41, doi
  23. (1995). Macromolecular IgA and abnormal IgA reactivity in sera from children with IgA nephropathy. Italian Collaborative Paediatric IgA Nephropathy Study. Clin Nephrol 43:1-13.,
  24. (1995). Memory B lymphocytes in human tonsil do not express surface IgD.
  25. (2006). O-glycosylation of serum IgD in IgA nephropathy.
  26. (1991). PD: Regulation of IgM and IgD expression in human B-lineage cells.
  27. (1983). Quantitation of immunoglobulin-producing cells in small intestinal mucosa of patients with IgA nephropathy. Clin Immunol Immunopathol 26:442-445, doi
  28. (2000). RP: IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genet 26:354-357., doi
  29. (1993). S: Selective expression of integrin alpha 4 beta 7 on a subset of human CD4+ memory T cells with Hallmarks of gut-trophism.
  30. (1999). Salupere V: IgA-antigliadin antibodies in patients with IgA nephropathy: the secondary phenomenon? doi
  31. (1998). Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains. Nephron 78:290-295, doi
  32. (1983). Structures of the O-glycosidically linked oligosaccharides of human IgD.
  33. (1993). Systemic and mucosal IgA responses to systemic antigen challenge in IgA nephropathy. Clin Immunol Immunopathol 69:306-313., doi
  34. (1998). The nucleotide sequence of the IgA1 hinge region in IgA nephropathy. doi
  35. (1979). TL: Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain.
  36. (1989). van Es LA: Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy. doi
  37. (2007). Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Kidney Int, doi
  38. (1996). Youinou P: Aberrant glycosylation of IgA from patients with IgA nephropathy. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.