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Modulation of response to cancer chemotherapeutic agents by diet constituents: is the available evidence sufficiently robust for rational advice for patients?

By M. D'Incalci, William P. Steward and Andreas J. Gescher

Abstract

This is the authors' final draft of the paper published as Cancer Treatment Reviews, 2007, 33(3), pp. 223-9, DOI: 10.1016/j.ctrv.2006.12.004Background: Patients who are diagnosed with cancer want advice on how they may alter their diet or which diet supplements they should take to augment chemotherapy.\ud Methods: We conducted a review of the literature mostly from the last 15 years on\ud the interaction between dietary constituents and antineoplastic therapy in preclinical\ud rodent models and in clinical trials.\ud Results: Studies have explored the effect of predominantly antioxidant vitamins and\ud folate on efficacy or toxicity mediated by cisplatin and anthracyclins. Cisplatin\ud toxicity in rodents was ameliorated by vitamin E. The design of clinical studies of\ud dietary agents in combination with cytotoxic agents has been very heterogeneous and\ud results have been inconclusive.\ud Conclusions: Whilst preclinical experiments hint at a potential benefit of certain\ud dietary agents, the evidence emanating from clinical studies does not allow firm\ud conclusions to be made. Future studies should explore physiological doses of dietary\ud agent and include pharmacokinetic and pharmacodynamic measurements

Publisher: Elsevier
Year: 2007
DOI identifier: 10.1016/j.ctrv.2006.12.004
OAI identifier: oai:lra.le.ac.uk:2381/855

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Citations

  1. (2001). A phase I study of vitamin E, 5-fluorouracil and leucovorin for advanced malignancies. Invest New Drugs
  2. (2004). Antioxidants and cancer therapy: a systematic review.
  3. (2005). Assessment of dietary questionnaire in cancer patients receiving cytotoxic chemotherapy.
  4. (2003). Cancer prevention with dietary phytochemicals. doi
  5. (1996). Cardioprotection in patients undergoing chemo- and/or radiotherapy for neoplastic disease. A pilot study. doi
  6. (1982). Clinical and pharmacological investigation of the effects of alpha-tocopherol on adriamycin cardiotoxicity. doi
  7. (2006). Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin. doi
  8. (2005). Cruciferae interact with the UGT1A1*28 polymorphism to determine serum bilirubin levels in humans.
  9. (2004). Effect of vitamin B12, folate, and dietary supplements on breast carcinoma chemotherapy – induced mucositis and neutropenia. Cancer doi
  10. (2003). Grapefruit juice and potential drug interactions. Consult Pharm
  11. (1986). High dose alpha-tocopherol as a preventive of doxorubicin-induced alopecia. Cancer Ther Rep
  12. (2002). High folate diets and brest cancer survival in a prospective cohort study. Nutr Cancer doi
  13. (2003). Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. doi
  14. (2006). Nutritional interventions and outcome in patients with cancer or preinvasive lesions: systematic review. doi
  15. (2003). Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev doi
  16. (1980). Prospective study of tocopherol prophylaxis for anthracycline cardiac toxicity. Current Ther Res
  17. (2000). Protective role of selenium against the toxicity of multi-drug chemotherapy in patients with ovarian cancer. Pharmazie
  18. (2004). Selective modulation of the therapeutic efficacvy of anticancer drugs by selenium containing compounds against human tumor xenografts. Clinical Cancer Res doi
  19. (2005). Selenium supplementation may increase the efficacy of cetuximab in metastatic colorectal cancer patients. Med Hypoth doi
  20. (2004). Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised double-blind, placebo-controlled study. doi
  21. (1997). The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients. Biol Trace Elem Res doi
  22. (2006). Toward a core nutraceutical program for cancer management. Integr Cancer Ther
  23. (2005). Use of antioxidants during chemotherapy and radiotherapy should be avoided. doi

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