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Increased spatial resolution using a three-dimensional T1-weighted gradient-echo MR sequence results in greater hypointense lesion volumes in multiple sclerosis

By Massimo Filippi, Maria A. Rocca, Mark A. Horsfield, Marco Rovaris, C. Pereira, T.A. Yousry, B. Colombo and G. Comi


This article was published in American Journal of Neuroradiology, and is available at their website at Our goal was to evaluate whether improved spatial resolution of MR images results in the detection of higher volumes of hypointense lesions in patients with multiple sclerosis (MS). METHODS: A magnetization-prepared rapid acquisition gradient-echo (MP-RAGE) sequence with subsequent reconstruction of axial sections with 5-, 3-, and 1-mm thickness and a dual-echo sequence were obtained in 16 patients with relapsing-remitting or secondary-progressive MS. The volumes of MR imaging abnormalities present on each of these studies were measured using a semiautomated segmentation technique based on local thresholding. The hypointense lesion volumes seen on the three reconstructed MP-RAGE sets of images were compared using the Friedman test and correlated with the hyperintense lesion volume on proton density-weighted images and with scores on the Expanded Disability Status Scale using Spearman's rank correlation coefficient. RESULTS: The median volume of hypointense lesions increased from 1.2 mL (range, 0 to 14.9 mL) on the 5-mm-thick MP-RAGE images to 1.7 mL (range, 0 to 15.8 mL) on the 3-mm-thick images, and to 1.9 mL (range, 0 to 16.2 mL) on the 1-mm-thick images. The hypointense lesion volumes measured on the three MP-RAGE images correlated significantly with the degree of disability, whereas this correlation was not significant with the T2- weighted lesion load. CONCLUSION: Our findings indicate that a significant increase in the volume of potentially disabling MS lesions is observed when obtaining MR images with thin sections

Publisher: American Society of Neuroradiology
Year: 1998
OAI identifier:

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  1. (1996). A high- resolution three-dimensional T1-weighted gradient echo sequence improves the detection of disease activity in multiple sclerosis. doi
  2. (1996). Assessment of lesion pathology in multiple sclerosis using quantitative MR morphometry and magnetic resonance spectroscopy. doi
  3. (1995). Characterization of multiple sclerosis plaques with T1-weighted MR and quantitative magnetization transfer.
  4. Correlation of magnetization transfer ratio with disability in multiple sclerosis. doi
  5. (1996). Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis. doi
  6. (1997). Hypointense lesions on T1-weighted SE MR imgages correlate with axonal loss in multiple sclerosis. Presented at the annual meeting of the International Society for Magnetic Resonance in Medicine,
  7. (1995). Intra- and inter-observer agreement of brain MRI lesion volume measurements in multiple sclerosis: a comparison of techniques. doi
  8. (1996). Magnetic resonance imaging (MRI) in the differential diagnosis and monitoring the treatment of multiple sclerosis. doi
  9. (1991). Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. doi
  10. (1994). Magnetization transfer in multiple sclerosis. doi
  11. (1992). MP RAGE: a threedimensional, T1-weighted gradient-echo sequence: initial experience in the brain. Radiology doi
  12. (1995). Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axonal loss. doi
  13. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). doi
  14. (1996). Reingold SC, the National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Defining the clinical course of multiple sclerosis: results of an international survey. doi
  15. (1995). Resolution-dependent estimates of lesion volumes in magnetic resonance imaging studies of the brain in multiple sclerosis. doi
  16. (1997). Sensitivity and reproducibility of fast-FLAIR, FSE and TGSE sequences for the assessment of brain MRI lesion load in multiple sclerosis: a preliminary study. doi
  17. (1996). Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression. doi
  18. (1990). Three-dimensional magnetization- prepared rapid gradient-echo imaging (3D MP RAGE). Magn Reson Med doi
  19. (1992). Volume T1-weighted gradient echo MRI in multiple sclerosis patients. doi

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