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Scan-Rescan Variation of Measures Derived from Brain Magnetization Transfer Ratio Histograms Obtained in Healthy Volunteers by Use of a Semi-interleaved Magnetization Transfer Sequence

By Matilde Inglese, Mark A. Horsfield and Massimo Filippi


This is the version as published by American Society of Neuroradiology. It is available online at A novel semiinterleaved gradient-echo (GE) sequence for quantitative measurement of magnetization transfer ratio (MTR) is described. With this sequence, several lines of k-space are collected for the non-MT image then several lines are collected for the MT image, thus building up the entire k-space in distinct acquisition blocks, with a good trade-off between motion-induced misregistration and degree of MT effect. The scan-rescan coefficients of variation for several MTR histogram-derived measures from 10 healthy volunteers scanned serially with this semiinterleaved sequence proved to be lower than those achieved using a conventional GE sequence. This sequence may be useful in a clinical environment to measure MTR changes over time more reliably than when acquiring the non-MT and MT images sequentially, which inevitably are affected by patient motion

Publisher: American Society of Neuroradiology.
Year: 2001
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