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Scan-Rescan Variation of Measures Derived from Brain Magnetization Transfer Ratio Histograms Obtained in Healthy Volunteers by Use of a Semi-interleaved Magnetization Transfer Sequence

By Matilde Inglese, Mark A. Horsfield and Massimo Filippi

Abstract

This is the version as published by American Society of Neuroradiology. It is available online at http://www.ajnr.org/cgi/reprint/22/4/681Summary: A novel semiinterleaved gradient-echo (GE) sequence for quantitative measurement of magnetization transfer ratio (MTR) is described. With this sequence, several lines of k-space are collected for the non-MT image then several lines are collected for the MT image, thus building up the entire k-space in distinct acquisition blocks, with a good trade-off between motion-induced misregistration and degree of MT effect. The scan-rescan coefficients of variation for several MTR histogram-derived measures from 10 healthy volunteers scanned serially with this semiinterleaved sequence proved to be lower than those achieved using a conventional GE sequence. This sequence may be useful in a clinical environment to measure MTR changes over time more reliably than when acquiring the non-MT and MT images sequentially, which inevitably are affected by patient motion

Publisher: American Society of Neuroradiology.
Year: 2001
OAI identifier: oai:lra.le.ac.uk:2381/485

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