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Detection of multiple fluorescent labels using superconducting tunnel junction detectors.

By G. W. Fraser, J. S. (Pat) Heslop-Harrison, T. Schwarzacher, A. D. Holland, P. Verhoeve and A. Peacock

Abstract

This is the version as published by American Instiitute of physics. It is available online at http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=RSINAK000074000009004140000001&idtype=cvips&gifs=yesWe show that cryogenically cooled, photon counting superconducting tunnel junctions ~STJs! can be used to simultaneously record the optical spectra from multiple biological fluorochromes. Measurements with a single-pixel tantalum STJ with a wavelength resolving power R5l/Dl of about 10 confirm the expected sensitivity advantage with respect to the photomultiplier-based\ud detectors commonly used to record signals from microarrays and other fluorescent biological systems

Publisher: American Institute of Physics
Year: 2003
DOI identifier: 10.1063/1.1599059
OAI identifier: oai:lra.le.ac.uk:2381/421
Journal:

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Citations

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