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Primary hepatocytes as targets for hepatitis C virus replication

By M J Farquhar and Jane A McKeating

Abstract

Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry

Topics: R Medicine (General), QR355 Virology, QR180 Immunology, QR Microbiology
Year: 2008
OAI identifier: oai:eprints.bham.ac.uk:469

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