Hepatoprotective Effect Of Hibiscus Sabdariffa L Extract On 7,12-dimethylbenz(α)antracene (dmba) Induced Rat

Abstract

Rosella (H.sabdariffa L) extract has been reported to have antioxidants effect. Antioxidant has important role on detoxification and metabolism of xenobiotic. The objective of this study was to to investigate the effect of ethanolic extract from Roselle Calyx on activity of Serum Glutamic Pyruvic Transaminase (SGPT), Serum Glutamic Oxaloacetic Transaminase (SGOT), Alkaline phospatase (ALP) and liver histopathologic profile of Sprague Dawley (SD) rats induced by DMBA.The study found that activity of SGPT, SGOT and ALP were increase after DMBA treatment. The rosella extract showed to reduce the activity of SGPT, SGOT and ALP indicating hepatoprotective effect. The histopathology of liver rat induced by DMBA after 33 days treatment of rosella extract showed repairing effect on dependent manner Keywords:Hibiscus sabdariffa, hepatoprotective, SGPT,SGOT AL