journal article
oaioai:espace.library.uq.edu.au:UQ:313262

Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain

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Publication date
1 January 2014
Publisher
'Wiley'
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    Abstract

    ObjectiveThe pathobiology of prostate cancer (PCa)-induced bone pain (PCIBP) has both inflammatory and neuropathic components. Previously, we showed that small molecule angiotensin II type 2 receptor (AT(2)R) antagonists with >1,000-fold selectivity over the angiotensin II type 1 receptor produced dose-dependent analgesia in a rat model of neuropathic pain. Here, we assessed the analgesic efficacy and mode of action of the AT(2)R antagonist, EMA200, in a rat model of PCIBP

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    Last time updated on 14/12/2013

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