A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Abstract

A nanoparticle toolset was created within the size limits of 10–150 nm for probing size-dependent nanoparticle distribution in solid tumors. By using multiphoton intravital microscopy, the particles were tracked both spatially and temporally in the same tumor grown in a transparent window model.National Cancer Institute (U.S.) (Grant R01-CA126642)MIT-Harvard Center for Cancer Nanotechnology Excellence (National Institutes of Health (U.S.) 1U54-CA119349)Massachusetts Institute of Technology. Dept. of Chemistry Instrumentation Facility (CHE-980806)Massachusetts Institute of Technology. Dept. of Chemistry Instrumentation Facility (DBI-9729592)Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies (W911NF-07-D-0004)National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (DMR-0117795)National Science Foundation (U.S.). Climate Research Division (CHE-0714189)National Science Foundation (U.S.). Graduate Research Fellowship ProgramNovartis Foundation (Fellow of the Life Sciences Research Foundation