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Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks

By Jaroslav Hlinka and Stephen Coombes

Abstract

Ultra-slow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms

Publisher: American Physical Society
OAI identifier: oai:eprints.nottingham.ac.uk:1227
Provided by: Nottingham ePrints

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