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Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding

By Erik Keimpema, Klaudia Barabas, Yury M Morozov, Giuseppe Tortoriello, Masaaki Torii, Gary Cameron, Yuchio Yanagawa, Masahiko Watanabe, Ken Mackie and Tibor Harkany

Abstract

Peer reviewedPublisher PD

Topics: animals, arachidonic acids, axons, blotting, western, cells, cultured, chromatography, high pressure liquid, endocannabinoids, glutamate decarboxylase, glycerides, immunohistochemistry, lipoprotein lipase, mice, mice, inbred C57BL, microscopy, electron, monoacylglycerol lipases, neural pathways, neurons, pyramidal cells, receptor, cannabinoid, CB1, reverse transcriptase polymerase chain reaction, signal transduction, subcellular fractions, tandem mass spectrometry, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, RC0321
Year: 20
DOI identifier: 10.1523/JNEUROSCI.2126-10.2010
OAI identifier: oai:aura.abdn.ac.uk:2164/2221
Journal:

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Citations

  1. (1991). A doi
  2. (2007). A comprehensive profile of brain enzymesthathydrolyzetheendocannabinoid2-arachidonoylglycerol.Chem Biol 14:1347–1356. doi
  3. (2008). A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. doi
  4. (2001). Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons.
  5. (1999). Analysis of cannabinoid receptor binding and mRNA expression and endogenous cannabinoid contents in the developing rat brain during late gestation and early postnatal period. Synapse 33:181–191. doi
  6. (2008). Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. doi
  7. (2002). Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. doi
  8. (2009). BDNF regulates neuronal sensitivity to endocannabinoids. doi
  9. (2002). Brain monoglyceride lipase participating in endocannabinoid inactivation.
  10. (2010). Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. doi
  11. (1997). Cannabinoids inhibit N- and P/Qtype calcium channels in cultured rat hippocampal neurons.
  12. (2007). CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol Pharmacol 72:1557–1566. doi
  13. (2001). Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. doi
  14. (2001). Chemotropic responses of retinal growth conesmediatedbyrapidlocalproteinsynthesisanddegradation.Neuron 32:1013–1026. doi
  15. (2003). Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.
  16. (2006). Constitutive activation drives compartment-selective endocytosis and axonal targeting of type 1 cannabinoid receptors. doi
  17. (2006). Constitutiveactivationdrivescompartment-selectiveendocytosisand axonal targeting of type 1 cannabinoid receptors.
  18. Cravatt BF (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol 14:1347–1356. doi
  19. (1999). Derleth C,Mackie K
  20. (2008). Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. doi
  21. (2006). Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. doi
  22. (2010). Down-regulation of diacylglycerol lipase-alpha during neural stem cell differentiation: Identification of elements that regulate transcription. doi
  23. (2008). Endocannabinoid signaling controls pyramidal cell specification and longrange axon patterning. doi
  24. (2009). Endocannabinoid-mediated control of synaptic transmission.
  25. (2009). Endocannabinoid-mediated control of synaptic transmission. Physiol Rev 89:309–380. doi
  26. (2006). EndocannabinoidKeimpema et al. •Metabolic Control of 2-AG Signaling in Axons
  27. (2005). Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. doi
  28. (1999). Ferna ´ndez-Ruiz JJ doi
  29. (2008). Finazzi-Agro ` doi
  30. (2008). Graham A doi
  31. (2003). Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. doi
  32. (2003). Greenfluorescentproteinexpressionandcolocalizationwithcalretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. doi
  33. (2007). Hardwiring the brain: endocannabinoids shape neuronal connectivity. doi
  34. (2007). Hierarchical control of sensory neuron development by neurotrophic factors. doi
  35. (1995). How do thalamic axons find their way to the cortex? Trends Neurosci 18:389–397. doi
  36. (1995). Howdothalamicaxonsfindtheirwaytothe cortex? Trends Neurosci 18:389–397.
  37. (2007). Iba ´n ˜ez CF, Ernfors P
  38. (2009). Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. doi
  39. (2009). Integration of neuronalclonesintheradialcorticalcolumnsbyEphAandephrin-Asignalling. doi
  40. (1999). Internalizationandrecycling of the CB1 cannabinoid receptor.
  41. (2006). Localization of diacylglycerol lipase- around postsynaptic spine suggests close proximity between production site of an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. doi
  42. (2006). Localization of diacylglycerol lipase- around postsynapticspinesuggestscloseproximitybetweenproductionsiteof an endocannabinoid, 2-arachidonoyl-glycerol, and presynaptic cannabinoid CB1 receptor. doi
  43. (2010). Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. doi
  44. (2010). Metabolic Control of 2-AG Signaling in Axons
  45. (2006). Molecular composition of the endocannabinoid system at glutamatergic synapses.
  46. (2009). Monoacyl glycerol lipase (MGL) limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation (DSE) in autaptic hippocampal neurons. Mol Pharmacol 76:1220–1227. doi
  47. (2010). Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. doi
  48. (2010). Monoacylglycerollipaseregulatesafattyacidnetworkthatpromotescancer pathogenesis.
  49. (2002). Nerve growth cone guidance mediated by G protein-coupled receptors. doi
  50. (2001). Neurotrophins are required for nerve growth during development.
  51. (2009). Origin, early commitment, migratory routes, and destination of cannabinoid type 1 receptor-containing interneurons. doi
  52. (2007). Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. doi
  53. (2002). production and positioning of mouse neocortical neurons. Genes Dev 16:1760–1765.
  54. (2008). Pyramidal neurons grow up and change their mind. doi
  55. (2000). Quantification of bioactive acylethanolamides in rat plasma by electrospraymass spectrometry. doi
  56. (2000). Quantification of bioactiveacylethanolamidesinratplasmabyelectrospraymassspectrometry. doi
  57. (2003). Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.
  58. (2008). Roles of ubiquitination at the synapse. doi
  59. (2006). SCG10, a microtubule destabilizing factor, stimulates the neurite outgrowth by modulating microtubule dynamics in rat hippocampal primary cultured neurons. doi
  60. (2009). Secretagogin is a Ca 2-binding protein specifying subpopulations of telencephalic neurons.
  61. (2009). Secretagogin is a Ca2-binding protein specifying subpopulations of telencephalic neurons. doi
  62. (2004). Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. doi
  63. (2004). Segregation of two endocannabinoid-hydrolyzing enzymes into pre-andpostsynapticcompartmentsintherathippocampus,cerebellum and amygdala.
  64. (2009). Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. doi
  65. (2008). Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg Med Chem Lett 18:5838–5841. doi
  66. (2008). Selectivityofinhibitorsofendocannabinoidbiosynthesisevaluatedbyactivity-basedprotein profiling.
  67. (2007). Subcellular arrangement of molecules for 2-arachidonoylglycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. doi
  68. (2007). Subcellular arrangement of molecules for 2-arachidonoylglycerol-mediatedretrogradesignalinganditsphysiologicalcontribution to synaptic modulation in the striatum. doi
  69. (2010). The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. doi
  70. (2010). The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerollipasealphamediatesretrogradesuppressionofsynaptictransmission.
  71. (2005). The endocannabinoid system drives neural progenitor proliferation.
  72. (2006). The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells.
  73. (2006). The endocannabinoid systempromotesastroglialdifferentiationbyactingonneuralprogenitor cells.
  74. (1988). The establishment of polarity by hippocampal neurons in culture.
  75. (2003). The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response. doi
  76. (2008). The type 1 cannabinoid receptor is highly expressed in embryonic cortical projec14006 doi
  77. (2008). Thetype 1 cannabinoid receptor is highly expressed in embryonic cortical
  78. (1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
  79. (2007). URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. doi
  80. (2007). URB602inhibits monoacylglycerollipaseandselectivelyblocks2-arachidonoylglyceroldegradation in intact brain slices.
  81. (2008). Ya ´n ˜ez-Mun ˜oz RJ,

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