The goal of General Spatial Intelligence is to present a unified theory to support the various aspects of spatial experience, whether physical or cognitive. We acknowledge the fact that GIScience has to assume a particular worldview, resulting from specific positions regarding metaphysics, ontology, epistemology, mind, language, cognition and representation. Implicit positions regarding these domains may allow solutions to isolated problems but often hamper a more encompassing approach. We argue that explicitly defining a worldview allows the grounding and derivation of multi-modal models, establishing precise problems, allowing falsifiability. We present an example of such a theory founded on process metaphysics, where the ontological elements are called differences. We show that a worldview has implications regarding the nature of space and, in the case of the chosen metaphysical layer, favours a model of space as true spacetime, i.e. four-dimensionality. Finally we illustrate the approach using a scenario from psychology and AI based planning
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