Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

Goodell, John R.; McMullen, Jonathan P.; Zaborenko, Nikolay; Maloney, Jason R.; Ho, Chuan-Xing; Jensen, Klavs F.; Porco, John A.; Beeler, Aaron B.

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oai:dspace.mit.edu:1721.1/79348

Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

Authors: John R. Goodell
Jonathan P. McMullen
Nikolay Zaborenko
Jason R. Maloney
Chuan-Xing Ho
Klavs F. Jensen
John A. Porco
Aaron B. Beeler
Publication date: 1 May 2009
Publisher: American Chemical Society
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Abstract

An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo [3.2.1] octanoid scaffolds will be described.National Institute of General Medical Sciences (U.S.) (CMLD Initiative (P50 GM067041))Pfizer Inc.Merck Research LaboratoriesNational Science Foundation (U.S.) (NSF-REU program (CHE-0649114)

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