A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, Gyungah; Ibrahim-Verbaas, Carla A.; Vronskaya, Maria; Lambert, Jean-Charles; Chung, Jaeyoon; Naj, Adam C.; Kunkle, Brian W.; Wang, Li-San; Bis, Joshua C.; Bellenguez, C�line; Harold, Denise; Lunetta, Kathryn L.; Destefano, Anita L.; Grenier-Boley, Benjamin; Sims, Rebecca; Morgan, Kevin

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A novel Alzheimer disease locus located near the gene encoding tau protein

Authors: Gyungah Jun
Carla A. Ibrahim-Verbaas
Maria Vronskaya
Jean-Charles Lambert
Jaeyoon Chung
Adam C. Naj
Brian W. Kunkle
Li-San Wang
Joshua C. Bis
C�line Bellenguez
Denise Harold
Kathryn L. Lunetta
Anita L. Destefano
Benjamin Grenier-Boley
Rebecca Sims
Kevin Morgan
Publication date: 17 March 2015
Publisher: Nature Publishing Group
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Abstract

APOE ε4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’s Project (IGAP) Consortium in APOE ε4+ (10,352 cases and 9,207 controls) and APOE ε4- (7,184 cases and 26,968 controls) subgroups as well as in the total sample testing for interaction between a SNP and APOE ε4 status. Suggestive associations (

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