Absorbed dose kernel and self-shielding calculations for a novel radiopaque glass microsphere for transarterial radioembolization

Abstract

Purpose: Radiopaque microspheres may provide intraprocedural and postprocedural feedback during transarterial radioembolization (TARE). Furthermore, the potential to use higher resolution x\u2010ray imaging techniques as opposed to nuclear medicine imaging suggests that significant improvements in the accuracy and precision of radiation dosimetry calculations could be realized for this type of therapy. This study investigates the absorbed dose kernel for novel radiopaque microspheres including contributions of both short and long\u2010lived contaminant radionuclides while concurrently quantifying the self\u2010shielding of the glass network. Methods: Monte Carlo simulations using EGSnrc were performed to determine the dose kernels for all monoenergetic electron emissions and all beta spectra for radionuclides reported in a neutron activation study of the microspheres. Simulations were benchmarked against an accepted 90Y dose point kernel. Self\u2010shielding was quantified for the microspheres by simulating an isotropically emitting, uniformly distributed source, in glass and in water. The ratio of the absorbed doses was scored as a function of distance from a microsphere. The absorbed dose kernel for the microspheres was calculated for (a) two bead formulations following (b) two different durations of neutron activation, at (c) various time points following activation. Results: Self\u2010shielding varies with time postremoval from the reactor. At early time points, it is less pronounced due to the higher energies of the emissions. It is on the order of 0.4\u20132.8% at a radial distance of 5.43 mm with increased size from 10 to 50 \u3bcm in diameter during the time that the microspheres would be administered to a patient. At long time points, self\u2010shielding is more pronounced and can reach values in excess of 20% near the end of the range of the emissions. Absorbed dose kernels for 90Y, 90mY, 85mSr, 85Sr, 87mSr, 89Sr, 70Ga, 72Ga, and 31Si are presented and used to determine an overall kernel for the microspheres based on weighted activities. The shapes of the absorbed dose kernels are dominated at short times postactivation by the contributions of 70Ga and 72Ga. Following decay of the short\u2010lived contaminants, the absorbed dose kernel is effectively that of 90Y. After approximately 1000 h postactivation, the contributions of 85Sr and 89Sr become increasingly dominant, though the absorbed dose\u2010rate around the beads drops by roughly four orders of magnitude. Conclusions: The introduction of high atomic number elements for the purpose of increasing radiopacity necessarily leads to the production of radionuclides other than 90Y in the microspheres. Most of the radionuclides in this study are short\u2010lived and are likely not of any significant concern for this therapeutic agent. The presence of small quantities of longer lived radionuclides will change the shape of the absorbed dose kernel around a microsphere at long time points postadministration when activity levels are significantly reduced.Peer reviewed: YesNRC publication: Ye