F.M.M.-B. is supported by the British Heart Foundation grants CH/15/2/32064 and RG/14/2/30616 and by the Barts Charity grant MGU0377, G.M. is supported by the Fondazione Italiana Sclerosi Multipla (grant no. 2016/R/18), V.D.R. is supported by the Associazione Italiana per la Ricerca sul Cancro-Cariplo Transforming IDEas in Oncological Research (TRIDEO) (grant no. 17447), and G.D.N. is supported by Fondazione Cariplo2016-0852 and Ministero della SaluteGR-2011-02346974. D.M.S. is employed by and holds shares in AstraZeneca Plc
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