Metaplastic Cdx2-depleted cells can be very disruptive neighbors.

Abstract

In this issue of JEM, Balbinot et al. (https://doi.org/10.1084/jem.20170934) describe an original mechanism where Cdx2 inactivation regulates intestinal metaplastic to neoplastic transition in a paracrine fashion. Surprisingly, the target cells are neighboring "normal" Cdx2-positive cells

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Apollo (Cambridge)

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This paper was published in Apollo (Cambridge).

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