Delivery of cell therapies often requires the ability to hold products in
readiness whilst logistical, regulatory and potency considerations are
dealt with and recorded. This requires reversibly stopping biological time,
a process which is often achieved by cryopreservation. However, cryopreservation
itself poses many biological and biophysical challenges to living
cells that need to be understood in order to apply the low temperature
technologies to their best advantage. This review sets out the history of
applied cryopreservation, our current understanding of the various processes
involved in storage at cryogenic temperatures, and challenges for
robust and reliable uses of cryopreservation within the cell therapy arena
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