The influence of built environments on vitality and productivity of users is paramount. Since the introduction of Industrial, Flexible and Demountable Building, domotics, smart buildings, in general: mass-produced, intelligent and learning built environments, tailored built environments are within reach. This has resulted in the need for methodologies to predict short-term and long-term health effects of different built-environment constellations. Epidemiology has developed and validated methods to assess changes in prevalence of inflictions and other unhealthy conditions, as well as the number of healthy and vital years in a life span. After analysing the relationships among building (services) parts and its combinations, health determinants (exposures) and health outcomes, we could adapt the healthy years assessment (DALY) to changes in construction (insulation, air tightness) and building services engineering (ventilation, heating) for dwellings under Dutch conditions. The most important conclusion is that natural ventilation, mechanical ventilation and balanced ventilation not only differ in their average health effect, but even more so in the size of the ranges of these effects. Other systems, such as heat pumps or photo voltaic cells are expensive but will become economically applicable when healthcare costs are taken into account. These outcomes gave valuable clues for product innovation and opened the possibility to model health in relation to built environments. The method could also be applied to quality classification systems for dwellings.