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Metabolomics and pesticides: systematic literature review using graph theory for analysis of references

By Martha Zuluaga, Sebastian Robledo, German A. Osorio-Zuluaga2, Laura Yathe, Diana Gonzalez and Gonzalo Taborda


The systematic literature review presented here is designed to illustrate the role of metabonomics and metabolomics in pesticide exposure studies. The search was conducted in Thomson Reuters Web of Science (ISI Web of Knowledge) database. The references and citations for each article were downloaded for analysis. Graph theory was used to determine relevant articles and distinct relationships between classic and current research in this field through its structural characteristics. The initial network included 4423 nodes and 4978 links, from which indegree, outdegree and betweenness indicators were extracted. After preprocessing the data, the network was reduced to 415 nodes and 974 links. From this network, 80 articles with the highest score between the three indicators were extracted for review. This methodology allowed for the identification of different perspectives of metabolomic and metabonomic pesticide studies that included the mode and mechanism of action, toxicological and biological monitoring, environmental metabolomics, metabolism, dose response and biomarkers and its role in pesticide exposure

Topics: Metabonomics, Pesticides, Graph theory, Metabolomics, Ciencias Biol?gicas, Ciencias M?dicas
Publisher: NOVA
Year: 2016
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