A new dilophol diterpene, eunicidiol (<b>1</b>), has been isolated from the crude extract of <i>Eunicea fusca</i>, a gorgonian coral collected from Hillsboro Ledge, Florida. This compound was purified, along with fuscol (<b>2</b>) and eunicol (<b>3</b>), using a combination of normal- and reversed-phase chromatography methods. The structure of eunicidiol (<b>1</b>) was elucidated by 1D and 2D NMR spectroscopic analysis, and the absolute configuration was assigned using Mosher’s method. The anti-inflammatory activity of <b>1</b>–<b>3</b> was evaluated by measuring their ability to reduce phorbol myristate acetate (PMA)-induced edema in a mouse ear model. Topical application of a 100 μg/ear dose of diterpenes <b>1</b>–<b>3</b> significantly reduced edema by 44%, 46%, and 54%, respectively. This activity was superior to indomethacin, a known anti-inflammatory used as a control
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