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Analysis of activated CD8<sup>+</sup> T cells in peripheral bloods of scrub typhus patients.

By Bon-A Cho (142288), Youngho Ko (106905), Yeon-Sook Kim (142295), Sanguk Kim (88632), Myung-Sik Choi (106915), Ik-Sang Kim (106916), Hang-Rae Kim (137363) and Nam-Hyuk Cho (106918)


<p>PBMCs were stained with antibodies against CD8 and PD-1 or IL-7Rα and then analyzed on a flow cytometer. A and B. Representative histograms show the frequencies of IL-7Rα<sup>low</sup> cells (A) and PD-1<sup>high</sup> cells (B) within CD8<sup>+</sup> T cells. Gray histogram, isotype control. C. The frequency of IL-7Rα<sup>low</sup>CD8<sup>+</sup> T cells from healthy controls (HC, n = 9, open circle) is compared with that of scrub typhus patients at acute phase (AP, n = 7, gray circle) or convalescent phase (CP, n = 8, black circle). D. The frequencies of PD-1<sup>high</sup>CD8<sup>+</sup> T cells were compared among healthy controls (n = 9) and the patients (AP, n = 13; CP, n = 15). Red bars indicate the mean value and <i>p</i> values were obtained using the Mann-Whitney <i>U</i> test or Wilcoxon signed-rank test. Statistically significant <i>p</i> values (<0.05) are shown in bold.</p

Topics: Infectious Diseases, activated, cells, peripheral, bloods, scrub, typhus
Year: 2012
DOI identifier: 10.1371/journal.pntd.0001789.g006
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Provided by: FigShare
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