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Daily rhythms of home cage activity in young adult male mice under time-restrictive feeding regimen.

By Ji-Ae Yoon (140301), Dong-Hee Han (140305), Jong-Yun Noh (140308), Mi-Hee Kim (140311), Gi Hoon Son (140315), Kyungjin Kim (140317), Chang-Ju Kim (140320), Youngmi Kim Pak (140321) and Sehyung Cho (125616)

Abstract

<p>Young adult male mice, surgically implanted with E-mitter probes, were first entrained to a 12∶12 LD photoperiodic cycle for two weeks with food and water available <i>ad libitum</i>. Then mice were fed time-restrictively as schematized in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044053#pone-0044053-g001" target="_blank">Figure 1</a> for 4 weeks and returned to being fed <i>ad libitum</i>. Home cage activity (HCA) was continuously recorded for 7 subsequent weeks (See <i>M&M</i>). (A) Representative double-plot actograms of HCA in AF, DF, and NF mice. Dark rectangles above the actograms indicate the 12 h scotophase maintained throughout the experiment. (B) Daily patterns of HCA during the time-restrictive feeding. To generate the daily pattern of HCA, monitoring results for the whole time-restrictive period were summed up as 1 h bins and the resulting 28 day profiles were pooled according to the indicated ZT to generate the averaged daily pattern (mean ± S.E.M.). Statistical analyses are summarized in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044053#pone-0044053-t001" target="_blank">Table 1</a>. (C) Changes in daily HCA during the weeks of entrainment period (EP), 4 weeks of time-restrictive feeding (TR) and when returned to <i>ad libitum</i> feeding for 2 weeks (RA).</p

Topics: Physiology, Chemistry, Mental Health, rhythms, mice, time-restrictive, feeding
Year: 2012
DOI identifier: 10.1371/journal.pone.0044053.g003
OAI identifier: oai:figshare.com:article/257157
Provided by: FigShare
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