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Gold Branched Nanoparticles for Cellular Treatments

By Laura Sironi (244602), Stefano Freddi (1961518), Michele Caccia (11769), Paolo Pozzi (2049586), Leone Rossetti (2049589), Piersandro Pallavicini (1560409), Alice Donà (1873549), Elisa Cabrini (1560397), Maurizio Gualtieri (2049592), Ilaria Rivolta (244604), Alice Panariti (703350), Laura D’Alfonso (312345), Maddalena Collini (11768) and Giuseppe Chirico (11770)

Abstract

Under the action of near-infrared radiation, shape anisotropic gold nanoparticles emit two-photon luminescence and release heat. Accordingly, they have been proposed for imaging, photothermal therapies and thermo-controlled drug delivery. In all these applications particular care must be given to control the nanoparticle – cell interaction and the thermal efficiency of the nanoparticles, while minimizing their intrinsic cytotoxicity. We present here the characterization of the cell interaction of newly developed branched gold nanostars, obtained by laurylsulfobetaine-driven seed-growth synthesis. The study provides information on the size distribution, the shape anisotropy, the cellular uptake and cytotoxicity of the gold nanostars as well as their intracellular dynamic behavior by means of two-photon luminescence imaging, fluorescence correlation spectroscopy and particle tracking. The results show that the gold nanostars are internalized as well as the widely used gold nanorods and are less toxic under prolonged treatments. At the same time they display remarkable two-photon luminescence and large extinction under polarized light in the near-infrared region of the spectrum, 800–950 nm. Gold nanostars appear then a valuable alternative to other elongated or in-homogeneous nanoparticles for cell imaging

Topics: Biophysics, Cell Biology, Molecular Biology, Biotechnology, Ecology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, shape anisotropic gold nanoparticles, fluorescence correlation spectroscopy, gold Branched Nanoparticles, gold nanostars, imaging, luminescence
Year: 2012
DOI identifier: 10.1021/jp305021k.s004
OAI identifier: oai:figshare.com:article/2491939
Provided by: FigShare
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