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Tandem Catalysis for the Preparation of Cylindrical Polypeptide Brushes

By Allison J. Rhodes (1957282) and Timothy J. Deming (1359246)


Here, we report a method for synthesis of cylindrical copolypeptide brushes via <i>N</i>-carboxyanhydride (NCA) polymerization utilizing a new tandem catalysis approach that allows preparation of brushes with controlled segment lengths in a straightforward, one-pot procedure requiring no intermediate isolation or purification steps. To obtain high-density brush copolypeptides, we used a “grafting from” approach where alloc-α-aminoamide groups were installed onto the side chains of NCAs to serve as masked initiators. These groups were inert during cobalt-initiated NCA polymerization and gave allyloxycarbonyl-α-aminoamide-substituted polypeptide main chains. The alloc-α-aminoamide groups were then activated <i>in situ</i> using nickel to generate initiators for growth of side-chain brush segments. This use of stepwise tandem cobalt and nickel catalysis was found to be an efficient method for preparation of high-chain-density, cylindrical copolypeptide brushes, where both the main chains and side chains can be prepared with controlled segment lengths

Topics: Biophysics, Biochemistry, Microbiology, Cell Biology, Chemical Sciences not elsewhere classified, Cylindrical Polypeptide BrushesHere, tandem catalysis approach, polymerization, side chains, method, initiator, alloc, segment lengths, preparation, NCA, copolypeptide brushes
Year: 2012
DOI identifier: 10.1021/ja308620h.s001
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Provided by: FigShare
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