Monitoring the efficiency of detoxification therapy in newborn infants with ventilatorassociated pneumonia

Abstract

The efficiency of a fluorometric method for measuring the total and effective concentrations albumin and toxicity index in capillary blood was investigated in 60 neonates having a birth weight of 864 to 4020 g and bacterial pneumonia to evaluate the severity of endogenous toxicosis and to monitor detoxification therapy. The method can rapidly, objectively, and exactly estimate the adequately enhanced albumin functional activity that corresponds to an increase in total and effective blood albumin concentrations and a decrease in toxicity index by 20% or more. To alleviate the symptoms of pneumonia and infectious toxicity and to normalize both absolute albumin values and toxicity index are a ground to discontinue detoxification therapy. The method can substantially improve the objective monitoring of the efficiency of therapy for infectious toxicosis that complicates the course of bacterial pneumonia in newborns and ensure their adequate treatment