journal article
oaioai:espace.library.uq.edu.au:UQ:223524

Sry: the master switch in mammalian sex determination

Authors
Publication date
1 December 2010
Publisher
'The Company of Biologists'
Doi

    Abstract

    SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development. © Copyright 2010 The Company of Biologists Ltd

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