Skip to main content
Article thumbnail
Location of Repository

Should Magnesium Sulphate Prophylaxis be Used in all Cases of Severe Preeclampsia?

By Sohini Bhattacharya, Animesh Naskar, Sukanta Mondal, Ajanta Samanta and Shyama Pada Pati


A case control study, undertaken in the department of Obstetrics and Gynecology in a tertiary referral centre, was designed to administer standard dose of magnesium sulphate to 50 randomly selected severely preeclamptic women in labor (Group 1). 48 women who formed the control group did not receive the drug (Group 2). The admission – delivery interval, rate of Cesarean section showed no statistically significant difference. Four patients developed convulsions in Group 1 in contrast to twelve patients in Group 2. Efficacy of magnesium sulphate at preventing eclampsia was calculated as 68%. Mild respiratory depression occurred in two cases and oliguria in eight cases in Group 1. Both the conditions improved on suspending further doses of magnesium sulphate. No patient had post partum haemorrhage in Group 1 although 4% patients had it in Group 2. Neonatal outcome was comparable in both the groups. Hence magnesium sulphate may be regarded as a fairly safe and effective prophylactic agent for eclampsia when used in severe preeclampsia in labo

Topics: Online Journal of Health and Allied Sciences
Publisher: BS Kakkilaya
Year: 2011
OAI identifier:

Suggested articles


  1. American College of Obstetricians and Gynecologists:Management of preeclampsia.
  2. (2003). Diagnosis and management of gestational hypertension and preeclampsia. Obstetrics & Gynecology: High-risk pregnancy series: An expert’s view. doi
  3. (1998). Does magnesium sulfate given for prevention of eclampsia affect the outcome of labor? Am J Obstet Gynecol.
  4. (2008). Guidelines for the management of hypertensive disorders of pregnancy
  5. (2000). Is the prophylactic administration of magnesium sulphate in women with pre-eclampsia indicated prior to labour? BJOG doi
  6. (2000). Is the prophylactic administration of magnesium sulphate in women with preeclampsia indicated prior to labour?
  7. (2004). Magnesium sulfate in obstetrics: current data.
  8. (2004). Magnesium sulfate prophylaxis in preeclampsia: Lessons learned from recent trials. Am J Obstet Gynecol. doi
  9. (2006). Magnesium sulphate for the management of preeclampsia. Gynecol Obstet Fertil
  10. (2006). Magpie Trial Collaborative Group. Cost-effectiveness of prophylactic magnesium sulphate for 9996 women with preeclampsia from 33 contries: economic evaluation of te Magpie Trial. BJOG doi
  11. (2002). Magpie Trial Collaborative Group. Do women with preeclampsia, and their babies benefit from magnesium sulphate? The Magpie Trial: a randomized placebo controlled trial. Lancet. doi
  12. (2007). Magpie Trial Follow up Study Collaborative Group - The Magpie Trial: a randomized trial comparing magnesium sulfate with placebo for preeclampsia outcome for children at 18 months. BJOG doi
  13. (1992). Prophylaxis of eclamptic seizures: current controversies. Clin Obstet Gynecol
  14. (1996). Role of magnesium sulfate in seizure prevention in patients with eclampsia and preeclampsia. Drug Saf.
  15. (1997). The effect of magnesium sulfate therapy on the duration of labor in women with mild preeclampsia at term: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. doi

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.