A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

Authors
Publication date
1 January 2007
Publisher
Doi

    Abstract

    We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance P=0.045) was in the KIAA1109/Tenr/IL2/IL21 linkage disequilibrium block. Association was independently confirmed in two further collections (strongest at rs6822844, 24kB 5\u27 of IL21, meta-analysis P=1.3 ? 10?14, OR 0.63), suggesting genetic variation in this region predisposes to celiac disease

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    Irish Universities

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    Last time updated on 30/12/2017

    This paper was published in Irish Universities.

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