Article thumbnail

Immunohistochemical expression of PCNA, p53, bax and bcl-2 in oral lichen planus and epithelial dysplasia.

By Fernando A C G de Sousa, Thaís C Paradella, Yasmin R Carvalho and Luiz E B Rosa


The potential for malignant transformation of oral lichen planus is still controversial. The expression of proteins related to cell proliferation and apoptosis in oral lichen planus and epithelial dysplasia was analyzed to evaluate the true potential for malignant transformation of this disease. Twenty-four cases of each lesion were subjected to the streptoavidin-biotin technique for identifying the immunohistochemical expression of PCNA, p53, bax, and bcl-2 proteins. Of the 24 cases of oral lichen planus, 14 (58.33%) were positive for PCNA, 10 (41.67%) for p53, 4 (16.67%) for bcl-2 and 12 (50%) for bax, whereas of the 24 cases of epithelial dysplasia, 20 (83.33%) were positive for PCNA, 10 (41.67%) for p53, 6 (25%) for bcl-2, and 20 (83.33%) for bax. Chi-squared test showed no statistically significant differences between the expression of p53 and bcl-2 in oral lichen planus and epithelial dysplasia, regardless of the grade (P > 0.05). However, the expression of PCNA and bax was significantly increased in epithelial dysplasia (P < 0.05). The results of this study showed that alterations in expression of these proteins are observed in oral lichen planus and epithelial dysplasia, suggesting the potential for malignant transformation in both lesions

Topics: BAX protein, human, coloring agent, cycline, diagnostic agent, protein Bax, protein bcl 2, protein p53, apoptosis, cell proliferation, cell transformation, human, immunohistochemistry, lichen planus, mouth tumor, palatine tonsil, pathology, precancer, squamous cell carcinoma, Apoptosis, bcl-2-Associated X Protein, Carcinoma, Squamous Cell, Cell Proliferation, Cell Transformation, Neoplastic, Coloring Agents, Humans, Immunohistochemistry, Lichen Planus, Oral, Mouth Neoplasms, Palatine Tonsil, Precancerous Conditions, Proliferating Cell Nuclear Antigen, Proto-Oncogene Proteins c-bcl-2, Tumor Suppressor Protein p53
Year: 2009
DOI identifier: 10.2334/josnusd.51.117
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.