Recombinant Supercharged Polypeptides Restore and Improve Biolubrication

Busscher, Henk J.,; Mei, Henny C. van der,; Kolbe, Anke,; Veeregowda, Deepak H.,; Herrmann, Andreas,; Sharma, Prashant K.,

oai:ub.rug.nl:dbi/51d58efb02b34

Recombinant Supercharged Polypeptides Restore and Improve Biolubrication

Authors: Henk J., Busscher
Henny C. van der, Mei
Anke, Kolbe
Deepak H., Veeregowda
Andreas, Herrmann
Prashant K., Sharma
Publication date: 2013
Publisher

Abstract

Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.

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University of Groningen Digital Archive

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Last time updated on 06/08/2013

This paper was published in University of Groningen Digital Archive.

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