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Recombinant Supercharged Polypeptides Restore and Improve Biolubrication

By Henk J. Busscher, Henny C. van der Mei, Anke Kolbe, Deepak H. Veeregowda, Andreas Herrmann and Prashant K. Sharma

Abstract

Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.

Year: 2013
OAI identifier: oai:ub.rug.nl:dbi/51d58efb02b34
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