Although substantial progress has been made in the struggle against cancer, new anti-tumor strategies are still needed. A candidate strategy is the use of a so-called 'suicide gene' in combination with a prodrug. To this end, the herpes simplex virus thymidine kinase (HSV-tk)/ganciclovir (GCV) suicide gene/prodrug system has been extensively studied over the past fifteen years in preclinical and clinical settings (1). ... Zie: Summary
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