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Effect of alkaline phosphatase administration to mice with sepsis: exploration of a new strategy to detoxify endotoxin

By Hafida Bentala

Abstract

In this Ph.D. project we have explored the possibilities of using alkaline phosphatase to treat LPS-induced sepsis, by detoxifying this initiator of the disease. Sepsis is still a major problem worldwide, for which currently no effective treatment has been described that is applicable for most of the patients. LPS is a molecule from the outer membrane of Gram-negative bacteria, and it induces the production of many different inflammatory mediators after entering the body. See: summary, conclusion and perspectives.

Topics: Geneesmiddelen,, Endotoxinen; Septikemie; Fosfatasen; Proefschriften (vorm); farmacologie (geneeskunde)
Year: 2002
OAI identifier: oai:ub.rug.nl:dbi/4ab1e7ecbf712
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