Alterations in the expression of and response to growth factors is one of the biological characteristics of tumors. In chapter 1, a review is presented regarding the reported relations between p53 and growth factor regulation. The function of p53 tumor suppressor protein is determined by various intrinsic properties of the protein. The effect of p53 DNA-binding, and protein-protein interaction as determined by the conformation of the protein. Thus, p53 fulfils its role in cell cycle control and the onset of apoptotic cell death, which can be altered when the wild-type p53 (M-p53) conformation is changed after mutation. ... Zie: Summary and conclusions
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